Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. [electronic resource]
Producer: 20090820Description: 1694-7 p. digitalISSN:- 1464-3405
- Cell Cycle
- Cell Cycle Proteins -- antagonists & inhibitors
- Cell Line, Tumor
- Chemistry, Pharmaceutical -- methods
- Drug Design
- Humans
- Inhibitory Concentration 50
- Mitosis
- Models, Chemical
- Molecular Conformation
- Protein Binding
- Protein Kinase Inhibitors -- chemical synthesis
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Solubility
- Thiophenes -- chemistry
- Tumor Suppressor Proteins
- Polo-Like Kinase 1
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Publication Type: Journal Article
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