A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase. [electronic resource]
Producer: 20050225Description: 55827-32 p. digitalISSN:- 0021-9258
- Animals
- Benzamides
- Binding Sites
- Catalysis
- Catalytic Domain
- Crystallography, X-Ray
- Enzyme Precursors -- chemistry
- Hematopoietic Stem Cells -- metabolism
- Humans
- Hydrogen Bonding
- Imatinib Mesylate
- Insecta
- Intracellular Signaling Peptides and Proteins
- Ligands
- Models, Molecular
- Mutation
- Phosphorylation
- Piperazines -- pharmacology
- Protein Binding
- Protein Conformation
- Protein Structure, Tertiary
- Protein-Tyrosine Kinases -- chemistry
- Pyrimidines -- pharmacology
- Signal Transduction
- Staurosporine -- pharmacology
- Syk Kinase
- X-Rays
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
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