Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli. [electronic resource]
Producer: 20060117Description: 9893-901 p. digitalISSN:- 1529-2401
- Acid Sensing Ion Channels
- Animals
- Behavior, Animal
- Blotting, Northern -- methods
- Capsaicin -- pharmacology
- Cell Line
- Chlorocebus aethiops
- Cloning, Molecular -- methods
- Cricetinae
- Ganglia, Spinal -- cytology
- Gene Expression Regulation -- physiology
- Humans
- Hydrogen-Ion Concentration
- Inflammation -- genetics
- Male
- Membrane Proteins -- genetics
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutagenesis -- physiology
- Nerve Tissue Proteins -- genetics
- Neurons -- drug effects
- Oocytes
- Pain Measurement -- methods
- Patch-Clamp Techniques -- methods
- Physical Stimulation -- methods
- Protein Structure, Tertiary -- genetics
- Protein Subunits -- genetics
- Protons
- RNA, Messenger -- metabolism
- Reaction Time -- drug effects
- Reverse Transcriptase Polymerase Chain Reaction -- methods
- Sodium Channels -- genetics
- Time Factors
- Transfection -- methods
- Xenopus
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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