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81.
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Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats. [electronic resource] by
- Takahashi, Ryan
- Ma, Shuguang
- Deese, Alan
- Yue, Qin
- Kim-Kang, Heasook
- Yi, Yijun
- Siu, Michael
- Hunt, Kevin W
- Kallan, Nicholas C
- Hop, Cornelis E C A
- Liu, Xingrong
- Khojasteh, S Cyrus
Producer: 20141125
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 42
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82.
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83.
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Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans. [electronic resource] by
- Takahashi, Ryan H
- Choo, Edna F
- Ma, Shuguang
- Wong, Susan
- Halladay, Jason
- Deng, Yuzhong
- Rooney, Isabelle
- Gates, Mary
- Hop, Cornelis E C A
- Khojasteh, S Cyrus
- Dresser, Mark J
- Musib, Luna
Producer: 20160913
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 44
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84.
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Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition. [electronic resource] by
- Zhang, Chenghong
- Kenny, Jane R
- Le, Hoa
- Deese, Alan
- Ford, Kevin A
- Lightning, Luke K
- Fan, Peter W
- Driscoll, James P
- Halladay, Jason S
- Hop, Cornelis E C A
- Khojasteh, S Cyrus
Producer: 20120227
In:
Chemical research in toxicology vol. 24
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85.
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Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood-Brain Barrier Measured by Quantitative Targeted Proteomics. [electronic resource] by
- Billington, Sarah
- Salphati, Laurent
- Hop, Cornelis E C A
- Chu, Xiaoyan
- Evers, Raymond
- Burdette, Doug
- Rowbottom, Christopher
- Lai, Yurong
- Xiao, Guangqing
- Humphreys, W Griffith
- Nguyen, Tot Bui
- Prasad, Bhagwat
- Unadkat, Jashvant D
Producer: 20200330
In:
Clinical pharmacology and therapeutics vol. 106
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86.
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87.
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Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4. [electronic resource] by
- Kalgutkar, Amit S
- Vaz, Alfin D N
- Lame, Mary E
- Henne, Kirk R
- Soglia, John
- Zhao, Sabrina X
- Abramov, Yuri A
- Lombardo, Franco
- Collin, Claire
- Hendsch, Zachary S
- Hop, Cornelis E C A
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In:
Drug metabolism and disposition: the biological fate of chemicals vol. 33
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88.
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An individualized approach to sustained inflation duration at birth improves outcomes in newborn preterm lambs. [electronic resource] by
- Tingay, David G
- Lavizzari, Anna
- Zonneveld, Cornelis E E
- Rajapaksa, Anushi
- Zannin, Emanuela
- Perkins, Elizabeth
- Black, Don
- Sourial, Magdy
- Dellacà, Raffaele L
- Mosca, Fabio
- Adler, Andy
- Grychtol, Bartłomiej
- Frerichs, Inéz
- Davis, Peter G
Producer: 20160225
In:
American journal of physiology. Lung cellular and molecular physiology vol. 309
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89.
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Investigations into the mechanisms of pyridine ring cleavage in vismodegib. [electronic resource] by
- Khojasteh, S Cyrus
- Yue, Qin
- Ma, Shuguang
- Castanedo, Georgette
- Chen, Jacob Z
- Lyssikatos, Joseph
- Mulder, Teresa
- Takahashi, Ryan
- Ly, Justin
- Messick, Kirsten
- Jia, Wei
- Liu, Lichuan
- Hop, Cornelis E C A
- Wong, Harvey
Producer: 20140926
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 42
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90.
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Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry. [electronic resource] by
- Liang, Xiaorong
- Van Parys, Michael
- Ding, Xiao
- Zeng, Ning
- Bi, Luke
- Dorshort, Drew
- McKnight, Janine
- Milanowski, Dennis
- Mao, Jialin
- Chen, Yuan
- Ware, Joseph A
- Dean, Brian
- Hop, Cornelis E C A
- Deng, Yuzhong
Producer: 20161213
In:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences vol. 1020
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91.
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A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry. [electronic resource] by
- Graham, Richard A
- Lum, Bert L
- Morrison, Glenn
- Chang, Ilsung
- Jorga, Karin
- Dean, Brian
- Shin, Young G
- Yue, Qin
- Mulder, Teresa
- Malhi, Vikram
- Xie, Minli
- Low, Jennifer A
- Hop, Cornelis E C A
Producer: 20111209
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 39
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92.
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Corrigendum to "Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry" [J. Chromatogr. B 1020 (2016) 111-119]. [electronic resource] by
- Liang, Xiaorong
- Van Parys, Michael
- Ding, Xiao
- Zeng, Ning
- Bi, Luke
- Dorshorst, Drew
- McKnight, Janine
- Milanowski, Dennis
- Mao, Jialin
- Chen, Yuan
- Ware, Joseph A
- Dean, Brian
- Hop, Cornelis E C A
- Deng, Yuzhong
Publication details: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 09 2016
In:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences vol. 1029-1030
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93.
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Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp. [electronic resource] by
- Takahashi, Ryan
- Ma, Shuguang
- Yue, Qin
- Kim-Kang, Heasook
- Yi, Yijun
- Lyssikatos, Joseph P
- Regal, Kelly
- Hunt, Kevin W
- Kallan, Nicholas C
- Siu, Michael
- Hop, Cornelis E C A
- Liu, Xingrong
- Khojasteh, S Cyrus
Producer: 20150831
In:
European journal of drug metabolism and pharmacokinetics vol. 40
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94.
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Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper. [electronic resource] by
- Prasad, Bhagwat
- Achour, Brahim
- Artursson, Per
- Hop, Cornelis E C A
- Lai, Yurong
- Smith, Philip C
- Barber, Jill
- Wisniewski, Jacek R
- Spellman, Daniel
- Uchida, Yasuo
- Zientek, Michael A
- Unadkat, Jashvant D
- Rostami-Hodjegan, Amin
Producer: 20200511
In:
Clinical pharmacology and therapeutics vol. 106
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95.
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Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates. [electronic resource] by
- Zhang, Donglu
- Fourie-O'Donohue, Aimee
- Dragovich, Peter S
- Pillow, Thomas H
- Sadowsky, Jack D
- Kozak, Katherine R
- Cass, Robert T
- Liu, Liling
- Deng, Yuzhong
- Liu, Yichin
- Hop, Cornelis E C A
- Khojasteh, S Cyrus
Producer: 20200601
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 47
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96.
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Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs. [electronic resource] by
- Takahashi, Ryan H
- Ma, Shuguang
- Yue, Qin
- Kim-Kang, Heasook
- Yi, Yijun
- Ly, Justin
- Boggs, Jason W
- Fettes, Alec
- McClory, Andrew
- Deng, Yuzhong
- Hop, Cornelis E C A
- Khojasteh, S Cyrus
- Choo, Edna F
Producer: 20170223
In:
Xenobiotica; the fate of foreign compounds in biological systems vol. 47
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97.
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Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates. [electronic resource] by
- Zhang, Donglu
- Yu, Shang-Fan
- Khojasteh, S Cyrus
- Ma, Yong
- Pillow, Thomas H
- Sadowsky, Jack D
- Su, Dian
- Kozak, Katherine R
- Xu, Keyang
- Polson, Andrew G
- Dragovich, Peter S
- Hop, Cornelis E C A
Producer: 20190409
In:
Molecular cancer therapeutics vol. 17
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98.
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Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947. [electronic resource] by
- Liu, Xingrong
- Liang, Xiaorong
- LeCouter, Jenninfer
- Ubhayakar, Savita
- Chen, Jacob
- Cheng, Jay
- Lee, Tom
- Lubach, Joe
- Nonomiya, Jim
- Shahidi-Latham, Sheerin
- Quiason, Cristine
- Solon, Eric
- Wright, Matthew
- Hop, Cornelis E C A
- Heffron, Timothy P
Producer: 20210719
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 48
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99.
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Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study. [electronic resource] by
- Prasad, Bhagwat
- Bhatt, Deepak Kumar
- Johnson, Katherine
- Chapa, Revathi
- Chu, Xiaoyan
- Salphati, Laurent
- Xiao, Guangqing
- Lee, Caroline
- Hop, Cornelis E C A
- Mathias, Anita
- Lai, Yurong
- Liao, Mingxiang
- Humphreys, William G
- Kumer, Sean C
- Unadkat, Jashvant D
Producer: 20181113
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 46
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100.
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Effectiveness of individualized lung recruitment strategies at birth: an experimental study in preterm lambs. [electronic resource] by
- Tingay, David G
- Rajapaksa, Anushi
- Zannin, Emanuela
- Pereira-Fantini, Prue M
- Dellaca, Raffaele L
- Perkins, Elizabeth J
- Zonneveld, Cornelis E E
- Adler, Andy
- Black, Don
- Frerichs, Inéz
- Lavizzari, Anna
- Sourial, Magdy
- Grychtol, Bartłomiej
- Mosca, Fabio
- Davis, Peter G
Producer: 20170612
In:
American journal of physiology. Lung cellular and molecular physiology vol. 312
Availability: No items available.
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