Results
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61.
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Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead. [electronic resource] by
- Jones, Carrie K
- Sheffler, Douglas J
- Williams, Richard
- Jadhav, Sataya B
- Felts, Andrew S
- Morrison, Ryan D
- Niswender, Colleen M
- Daniels, J Scott
- Conn, P Jeffrey
- Lindsley, Craig W
Producer: 20141008
In:
Bioorganic & medicinal chemistry letters vol. 24
Availability: No items available.
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62.
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Biased M [electronic resource] by
- Moran, Sean P
- Xiang, Zixiu
- Doyle, Catherine A
- Maksymetz, James
- Lv, Xiaohui
- Faltin, Sehr
- Fisher, Nicole M
- Niswender, Colleen M
- Rook, Jerri M
- Lindsley, Craig W
- Conn, P Jeffrey
Producer: 20200831
In:
Science signaling vol. 12
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63.
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Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). [electronic resource] by
- Engers, Darren W
- Gentry, Patrick R
- Williams, Richard
- Bolinger, Julie D
- Weaver, C David
- Menon, Usha N
- Conn, P Jeffrey
- Lindsley, Craig W
- Niswender, Colleen M
- Hopkins, Corey R
Producer: 20101206
In:
Bioorganic & medicinal chemistry letters vol. 20
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64.
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M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location. [electronic resource] by
- Foster, Daniel J
- Gentry, Patrick R
- Lizardi-Ortiz, Jose E
- Bridges, Thomas M
- Wood, Michael R
- Niswender, Colleen M
- Sulzer, David
- Lindsley, Craig W
- Xiang, Zixiu
- Conn, P Jeffrey
Producer: 20140422
In:
The Journal of neuroscience : the official journal of the Society for Neuroscience vol. 34
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65.
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Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core. [electronic resource] by
- Nance, Kellie D
- Days, Emily L
- Weaver, C David
- Coldren, Anastasia
- Farmer, Tiffany D
- Cho, Hyekyung P
- Niswender, Colleen M
- Blobaum, Anna L
- Niswender, Kevin D
- Lindsley, Craig W
Producer: 20170616
In:
Journal of medicinal chemistry vol. 60
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66.
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Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. [electronic resource] by
- Wu, Huixian
- Wang, Chong
- Gregory, Karen J
- Han, Gye Won
- Cho, Hyekyung P
- Xia, Yan
- Niswender, Colleen M
- Katritch, Vsevolod
- Meiler, Jens
- Cherezov, Vadim
- Conn, P Jeffrey
- Stevens, Raymond C
Producer: 20140421
In:
Science (New York, N.Y.) vol. 344
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67.
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Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. [electronic resource] by
- Bridges, Thomas M
- Marlo, Joy E
- Niswender, Colleen M
- Jones, Carrie K
- Jadhav, Satyawan B
- Gentry, Patrick R
- Plumley, Hyekyung C
- Weaver, C David
- Conn, P Jeffrey
- Lindsley, Craig W
Producer: 20090701
In:
Journal of medicinal chemistry vol. 52
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68.
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Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics. [electronic resource] by
- Garcia-Barrantes, Pedro M
- Cho, Hyekyung P
- Niswender, Colleen M
- Byers, Frank W
- Locuson, Charles W
- Blobaum, Anna L
- Xiang, Zixiu
- Rook, Jerri M
- Conn, P Jeffrey
- Lindsley, Craig W
Producer: 20160202
In:
Journal of medicinal chemistry vol. 58
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69.
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Surveying heterocycles as amide bioisosteres within a series of mGlu [electronic resource] by
- Reed, Carson W
- Washecheck, Jordan P
- Quitlag, Marc C
- Jenkins, Matthew T
- Rodriguez, Alice L
- Engers, Darren W
- Blobaum, Anna L
- Conn, P Jeffrey
- Niswender, Colleen M
- Lindsley, Craig W
Producer: 20200225
In:
Bioorganic & medicinal chemistry letters vol. 29
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70.
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Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5. [electronic resource] by
- Felts, Andrew S
- Rodriguez, Alice L
- Morrison, Ryan D
- Blobaum, Anna L
- Byers, Frank W
- Daniels, J Scott
- Niswender, Colleen M
- Conn, P Jeffrey
- Lindsley, Craig W
- Emmitte, Kyle A
Producer: 20181218
In:
Bioorganic & medicinal chemistry letters vol. 28
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71.
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Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode. [electronic resource] by
- Digby, Gregory J
- Utley, Thomas J
- Lamsal, Atin
- Sevel, Christian
- Sheffler, Douglas J
- Lebois, Evan P
- Bridges, Thomas M
- Wood, Michael R
- Niswender, Colleen M
- Lindsley, Craig W
- Conn, P Jeffrey
Producer: 20130529
In:
ACS chemical neuroscience vol. 3
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72.
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An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. [electronic resource] by
- Shirey, Jana K
- Xiang, Zixiu
- Orton, Darren
- Brady, Ashley E
- Johnson, Kari A
- Williams, Richard
- Ayala, Jennifer E
- Rodriguez, Alice L
- Wess, Jürgen
- Weaver, David
- Niswender, Colleen M
- Conn, P Jeffrey
Producer: 20080108
In:
Nature chemical biology vol. 4
Availability: No items available.
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73.
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Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges. [electronic resource] by
- Kurata, Haruto
- Gentry, Patrick R
- Kokubo, Masaya
- Cho, Hyekyung P
- Bridges, Thomas M
- Niswender, Colleen M
- Byers, Frank W
- Wood, Michael R
- Daniels, J Scott
- Conn, P Jeffrey
- Lindsley, Craig W
Producer: 20150915
In:
Bioorganic & medicinal chemistry letters vol. 25
Availability: No items available.
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74.
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Differential Pharmacology and Binding of mGlu [electronic resource] by
- O'Brien, Daniel E
- Shaw, Douglas M
- Cho, Hyekyung P
- Cross, Alan J
- Wesolowski, Steven S
- Felts, Andrew S
- Bergare, Jonas
- Elmore, Charles S
- Lindsley, Craig W
- Niswender, Colleen M
- Conn, P Jeffrey
Producer: 20190213
In:
Molecular pharmacology vol. 93
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75.
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Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule. [electronic resource] by
- Poslusney, Michael S
- Melancon, Bruce J
- Gentry, Patrick R
- Sheffler, Douglas J
- Bridges, Thomas M
- Utley, Thomas J
- Daniels, J Scott
- Niswender, Colleen M
- Conn, P Jeffrey
- Lindsley, Craig W
- Wood, Michael R
Producer: 20130903
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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76.
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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1. [electronic resource] by
- Manka, Jason T
- Rodriguez, Alice L
- Morrison, Ryan D
- Venable, Daryl F
- Cho, Hyekyung P
- Blobaum, Anna L
- Daniels, J Scott
- Niswender, Colleen M
- Conn, P Jeffrey
- Lindsley, Craig W
- Emmitte, Kyle A
Producer: 20140331
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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77.
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Corrigendum to "Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres" [Bioorg. Med. Chem. Lett. 24 (2014) 1062-1066]. [electronic resource] by
- Sheffler, Douglas J
- Nedelcovych, Michael T
- Williams, Richard
- Turner, Stephen C
- Duerk, Brittany B
- Robbins, Megan R
- Jadhav, Sataya B
- Niswender, Colleen M
- Jones, Carrie K
- Conn, P Jeffrey
- Nathan Daniels, R
- Lindsley, Craig W
Publication details: Bioorganic & medicinal chemistry letters 05 2017
In:
Bioorganic & medicinal chemistry letters vol. 27
Availability: No items available.
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78.
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Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists. [electronic resource] by
- Poslusney, Michael S
- Sevel, Christian
- Utley, Thomas J
- Bridges, Thomas M
- Morrison, Ryan D
- Kett, Nathan R
- Sheffler, Douglas J
- Niswender, Colleen M
- Daniels, J S
- Conn, P J
- Lindsley, Craig W
- Wood, Michael R
Producer: 20130314
In:
Bioorganic & medicinal chemistry letters vol. 22
Availability: No items available.
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79.
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Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres. [electronic resource] by
- Sheffler, Douglas J
- Nedelcovych, Michael T
- Williams, Richard
- Turner, Stephen C
- Duerk, Brittany B
- Robbins, Megan R
- Jadhav, Sataya B
- Niswender, Colleen M
- Jones, Carrie K
- Conn, P Jeffrey
- Daniels, R Nathan
- Lindsley, Craig W
Producer: 20141008
In:
Bioorganic & medicinal chemistry letters vol. 24
Availability: No items available.
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80.
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Discovery of structurally distinct tricyclic M [electronic resource] by
- Temple, Kayla J
- Long, Madeline F
- Engers, Julie L
- Watson, Katherine J
- Chang, Sichen
- Luscombe, Vincent B
- Rodriguez, Alice L
- Niswender, Colleen M
- Bridges, Thomas M
- Conn, P Jeffrey
- Engers, Darren W
- Lindsley, Craig W
Producer: 20210128
In:
Bioorganic & medicinal chemistry letters vol. 30
Availability: No items available.
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