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Evaluation of metabolism and disposition of GDC-0152 in rats using 14C labeling strategy at two different positions: a novel formation of hippuric acid from 4-phenyl-5-amino-1,2,3-thiadiazole. [electronic resource] by
- Yue, Qin
- Mulder, Teresa
- Rudewicz, Patrick J
- Solon, Eric
- Budha, Nageshwar
- Ware, Joseph A
- Lyssikatos, Joseph
- Hop, Cornelis E C A
- Wong, Harvey
- Khojasteh, S Cyrus
Producer: 20130712
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 41
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65.
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An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software. [electronic resource] by
- Shah, Pranav
- Kerns, Edward
- Nguyen, Dac-Trung
- Obach, R Scott
- Wang, Amy Q
- Zakharov, Alexey
- McKew, John
- Simeonov, Anton
- Hop, Cornelis E C A
- Xu, Xin
Producer: 20180206
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 44
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A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation. [electronic resource] by
- Kumar, Vineet
- Salphati, Laurent
- Hop, Cornelis E C A
- Xiao, Guangqing
- Lai, Yurong
- Mathias, Anita
- Chu, Xiaoyan
- Humphreys, W Griffith
- Liao, Mingxiang
- Heyward, Scott
- Unadkat, Jashvant D
Producer: 20200123
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 47
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Absorption, distribution, metabolism, and excretion of [¹⁴C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening. [electronic resource] by
- Yue, Qin
- Chen, Yung-Hsiang
- Mulder, Teresa
- Deese, Alan
- Takahashi, Ryan
- Rudewicz, Patrick J
- Reynolds, Mark
- Solon, Eric
- Hop, Cornelis E C A
- Wong, Harvey
- Khojasteh, S Cyrus
Producer: 20110912
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 39
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71.
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Antibody Drug Conjugates Differentiate Uptake and DNA Alkylation of Pyrrolobenzodiazepines in Tumors from Organs of Xenograft Mice. [electronic resource] by
- Ma, Yong
- Khojasteh, S Cyrus
- Hop, Cornelis E C A
- Erickson, Hans K
- Polson, Andrew
- Pillow, Thomas H
- Yu, Shang-Fan
- Wang, Hong
- Dragovich, Peter S
- Zhang, Donglu
Producer: 20180111
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 44
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Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects. [electronic resource] by
- Graham, Richard A
- Hop, Cornelis E C A
- Borin, Marie T
- Lum, Bert L
- Colburn, Dawn
- Chang, Ilsung
- Shin, Young G
- Malhi, Vikram
- Low, Jennifer A
- Dresser, Mark J
Producer: 20130306
In:
British journal of clinical pharmacology vol. 74
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76.
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Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response. [electronic resource] by
- Wong, Harvey
- Choo, Edna F
- Alicke, Bruno
- Ding, Xiao
- La, Hank
- McNamara, Erin
- Theil, Frank-Peter
- Tibbitts, Jay
- Friedman, Lori S
- Hop, Cornelis E C A
- Gould, Stephen E
Producer: 20130403
In:
Clinical cancer research : an official journal of the American Association for Cancer Research vol. 18
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77.
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Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues. [electronic resource] by
- Zhang, Donglu
- Dragovich, Peter S
- Yu, Shang-Fan
- Ma, Yong
- Pillow, Thomas H
- Sadowsky, Jack D
- Su, Dian
- Wang, Wei
- Polson, Andrew
- Khojasteh, S Cyrus
- Hop, Cornelis E C A
Producer: 20200601
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 47
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78.
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Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS. [electronic resource] by
- Liang, Xiaorong
- Yang, Lulu
- Qin, Ann R
- Ly, Justin
- Liederer, Bianca M
- Messick, Kirsten
- Ma, Shuguang
- Zak, Mark
- Dragovich, Peter S
- Dean, Brian J
- Hop, Cornelis E C A
- Deng, Yuzhong
Producer: 20150302
In:
Bioanalysis vol. 6
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80.
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Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling. [electronic resource] by
- Wong, Harvey
- Theil, Frank-Peter
- Cui, Yong
- Marsters, James C
- Khojasteh, S Cyrus
- Vernillet, Laurent
- La, Hank
- Song, Xiling
- Wang, Hong
- Morinello, Eric J
- Deng, Yuzhong
- Hop, Cornelis E C A
Producer: 20101012
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 38
Availability: No items available.
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