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Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. [electronic resource] by
- Pei, Zhonghua
- Li, Xiaofeng
- von Geldern, Thomas W
- Madar, David J
- Longenecker, Kenton
- Yong, Hong
- Lubben, Thomas H
- Stewart, Kent D
- Zinker, Bradley A
- Backes, Bradley J
- Judd, Andrew S
- Mulhern, Mathew
- Ballaron, Stephen J
- Stashko, Michael A
- Mika, Amanda K
- Beno, David W A
- Reinhart, Glenn A
- Fryer, Ryan M
- Preusser, Lee C
- Kempf-Grote, Anita J
- Sham, Hing L
- Trevillyan, James M
Producer: 20061205
In:
Journal of medicinal chemistry vol. 49
Availability: No items available.
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40371.
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3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms. [electronic resource] by
- Ellsworth, Edmund L
- Tran, Tuan P
- Showalter, H D Hollis
- Sanchez, Joseph P
- Watson, Brian M
- Stier, Michael A
- Domagala, John M
- Gracheck, Stephen J
- Joannides, E Themis
- Shapiro, Martin A
- Dunham, Steve A
- Hanna, Debra L
- Huband, Michael D
- Gage, Jeffrey W
- Bronstein, Joel C
- Liu, Jia Yeu
- Nguyen, Dai Q
- Singh, Rajeshwar
Producer: 20061205
In:
Journal of medicinal chemistry vol. 49
Availability: No items available.
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40372.
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Further studies on imidazo[4,5-b]pyridine AT1 angiotensin II receptor antagonists. Effects of the transformation of the 4-phenylquinoline backbone into 4-phenylisoquinolinone or 1-phenylindene scaffolds. [electronic resource] by
- Cappelli, Andrea
- Pericot Mohr, Gal la
- Giuliani, Germano
- Galeazzi, Simone
- Anzini, Maurizio
- Mennuni, Laura
- Ferrari, Flora
- Makovec, Francesco
- Kleinrath, Eva M
- Langer, Thierry
- Valoti, Massimo
- Giorgi, Gianluca
- Vomero, Salvatore
Producer: 20061205
In:
Journal of medicinal chemistry vol. 49
Availability: No items available.
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