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Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target. [electronic resource] by
- Waters, Nigel J
- Daigle, Scott R
- Rehlaender, Bruce N
- Basavapathruni, Aravind
- Campbell, Carly T
- Jensen, Tyler B
- Truitt, Brett F
- Olhava, Edward J
- Pollock, Roy M
- Stickland, Kim A
- Dovletoglou, Angelos
Producer: 20161005
In:
Journal of controlled release : official journal of the Controlled Release Society vol. 220
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43.
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Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas. [electronic resource] by
- Naylor, Tara L
- Tang, Huaping
- Ratsch, Boris A
- Enns, Andreas
- Loo, Alice
- Chen, Liqing
- Lenz, Peter
- Waters, Nigel J
- Schuler, Walter
- Dörken, Bernd
- Yao, Yung-Mae
- Warmuth, Markus
- Lenz, Georg
- Stegmeier, Frank
Producer: 20110711
In:
Cancer research vol. 71
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44.
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Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in [electronic resource] by
- Campbell, Carly T
- Haladyna, Jessica N
- Drubin, David A
- Thomson, Ty M
- Maria, Michael J
- Yamauchi, Taylor
- Waters, Nigel J
- Olhava, Edward J
- Pollock, Roy M
- Smith, Jesse J
- Copeland, Robert A
- Blakemore, Stephen J
- Bernt, Kathrin M
- Daigle, Scott R
Producer: 20180626
In:
Molecular cancer therapeutics vol. 16
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45.
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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. [electronic resource] by
- Daigle, Scott R
- Olhava, Edward J
- Therkelsen, Carly A
- Basavapathruni, Aravind
- Jin, Lei
- Boriack-Sjodin, P Ann
- Allain, Christina J
- Klaus, Christine R
- Raimondi, Alejandra
- Scott, Margaret Porter
- Waters, Nigel J
- Chesworth, Richard
- Moyer, Mikel P
- Copeland, Robert A
- Richon, Victoria M
- Pollock, Roy M
Producer: 20131023
In:
Blood vol. 122
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46.
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Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. [electronic resource] by
- Duncan, Kenneth W
- Rioux, Nathalie
- Boriack-Sjodin, P Ann
- Munchhof, Michael J
- Reiter, Lawrence A
- Majer, Christina R
- Jin, Lei
- Johnston, L Danielle
- Chan-Penebre, Elayne
- Kuplast, Kristy G
- Porter Scott, Margaret
- Pollock, Roy M
- Waters, Nigel J
- Smith, Jesse J
- Moyer, Mikel P
- Copeland, Robert A
- Chesworth, Richard
Producer: 20160317
In:
ACS medicinal chemistry letters vol. 7
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47.
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Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. [electronic resource] by
- Mitchell, Lorna H
- Drew, Allison E
- Ribich, Scott A
- Rioux, Nathalie
- Swinger, Kerren K
- Jacques, Suzanne L
- Lingaraj, Trupti
- Boriack-Sjodin, P Ann
- Waters, Nigel J
- Wigle, Tim J
- Moradei, Oscar
- Jin, Lei
- Riera, Tom
- Porter-Scott, Margaret
- Moyer, Mikel P
- Smith, Jesse J
- Chesworth, Richard
- Copeland, Robert A
Producer: 20150623
In:
ACS medicinal chemistry letters vol. 6
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48.
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EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity. [electronic resource] by
- Campbell, John E
- Kuntz, Kevin W
- Knutson, Sarah K
- Warholic, Natalie M
- Keilhack, Heike
- Wigle, Tim J
- Raimondi, Alejandra
- Klaus, Christine R
- Rioux, Nathalie
- Yokoi, Akira
- Kawano, Satoshi
- Minoshima, Yukinori
- Choi, Hyeong-Wook
- Porter Scott, Margaret
- Waters, Nigel J
- Smith, Jesse J
- Chesworth, Richard
- Moyer, Mikel P
- Copeland, Robert A
Producer: 20150525
In:
ACS medicinal chemistry letters vol. 6
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49.
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Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor. [electronic resource] by
- Basavapathruni, Aravind
- Olhava, Edward J
- Daigle, Scott R
- Therkelsen, Carly A
- Jin, Lei
- Boriack-Sjodin, P Ann
- Allain, Christina J
- Klaus, Christine R
- Raimondi, Alejandra
- Scott, Margaret Porter
- Dovletoglou, Angelos
- Richon, Victoria M
- Pollock, Roy M
- Copeland, Robert A
- Moyer, Mikel P
- Chesworth, Richard
- Pearson, Paul G
- Waters, Nigel J
Producer: 20141215
In:
Biopharmaceutics & drug disposition vol. 35
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50.
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The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia. [electronic resource] by
- Stein, Eytan M
- Garcia-Manero, Guillermo
- Rizzieri, David A
- Tibes, Raoul
- Berdeja, Jesus G
- Savona, Michael R
- Jongen-Lavrenic, Mojca
- Altman, Jessica K
- Thomson, Blythe
- Blakemore, Stephen J
- Daigle, Scott R
- Waters, Nigel J
- Suttle, A Benjamin
- Clawson, Alicia
- Pollock, Roy
- Krivtsov, Andrei
- Armstrong, Scott A
- DiMartino, Jorge
- Hedrick, Eric
- Löwenberg, Bob
- Tallman, Martin S
Producer: 20190708
In:
Blood vol. 131
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51.
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Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. [electronic resource] by
- Mitchell, Lorna H
- Boriack-Sjodin, P Ann
- Smith, Sherri
- Thomenius, Michael
- Rioux, Nathalie
- Munchhof, Michael
- Mills, James E
- Klaus, Christine
- Totman, Jennifer
- Riera, Thomas V
- Raimondi, Alejandra
- Jacques, Suzanne L
- West, Kip
- Foley, Megan
- Waters, Nigel J
- Kuntz, Kevin W
- Wigle, Tim J
- Scott, Margaret Porter
- Copeland, Robert A
- Smith, Jesse J
- Chesworth, Richard
Producer: 20160317
In:
ACS medicinal chemistry letters vol. 7
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52.
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Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma. [electronic resource] by
- Drew, Allison E
- Moradei, Oscar
- Jacques, Suzanne L
- Rioux, Nathalie
- Boriack-Sjodin, Ann P
- Allain, Christina
- Scott, Margaret Porter
- Jin, Lei
- Raimondi, Alejandra
- Handler, Jessica L
- Ott, Heidi M
- Kruger, Ryan G
- McCabe, Michael T
- Sneeringer, Christopher
- Riera, Thomas
- Shapiro, Gideon
- Waters, Nigel J
- Mitchell, Lorna H
- Duncan, Kenneth W
- Moyer, Mikel P
- Copeland, Robert A
- Smith, Jesse
- Chesworth, Richard
- Ribich, Scott A
Producer: 20190730
In:
Scientific reports vol. 7
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53.
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Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. [electronic resource] by
- Knutson, Sarah K
- Kawano, Satoshi
- Minoshima, Yukinori
- Warholic, Natalie M
- Huang, Kuan-Chun
- Xiao, Yonghong
- Kadowaki, Tadashi
- Uesugi, Mai
- Kuznetsov, Galina
- Kumar, Namita
- Wigle, Tim J
- Klaus, Christine R
- Allain, Christina J
- Raimondi, Alejandra
- Waters, Nigel J
- Smith, Jesse J
- Porter-Scott, Margaret
- Chesworth, Richard
- Moyer, Mikel P
- Copeland, Robert A
- Richon, Victoria M
- Uenaka, Toshimitsu
- Pollock, Roy M
- Kuntz, Kevin W
- Yokoi, Akira
- Keilhack, Heike
Producer: 20141209
In:
Molecular cancer therapeutics vol. 13
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54.
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Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. [electronic resource] by
- Shultz, Michael D
- Cheung, Atwood K
- Kirby, Christina A
- Firestone, Brant
- Fan, Jianmei
- Chen, Christine Hiu-Tung
- Chen, Zhouliang
- Chin, Donovan N
- Dipietro, Lucian
- Fazal, Aleem
- Feng, Yun
- Fortin, Pascal D
- Gould, Ty
- Lagu, Bharat
- Lei, Huangshu
- Lenoir, Francois
- Majumdar, Dyuti
- Ochala, Etienne
- Palermo, M G
- Pham, Ly
- Pu, Minying
- Smith, Troy
- Stams, Travis
- Tomlinson, Ronald C
- Touré, B Barry
- Visser, Michael
- Wang, Run Ming
- Waters, Nigel J
- Shao, Wenlin
Producer: 20131029
In:
Journal of medicinal chemistry vol. 56
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55.
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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. [electronic resource] by
- Chan-Penebre, Elayne
- Kuplast, Kristy G
- Majer, Christina R
- Boriack-Sjodin, P Ann
- Wigle, Tim J
- Johnston, L Danielle
- Rioux, Nathalie
- Munchhof, Michael J
- Jin, Lei
- Jacques, Suzanne L
- West, Kip A
- Lingaraj, Trupti
- Stickland, Kimberly
- Ribich, Scott A
- Raimondi, Alejandra
- Scott, Margaret Porter
- Waters, Nigel J
- Pollock, Roy M
- Smith, Jesse J
- Barbash, Olena
- Pappalardi, Melissa
- Ho, Thau F
- Nurse, Kelvin
- Oza, Khyati P
- Gallagher, Kathleen T
- Kruger, Ryan
- Moyer, Mikel P
- Copeland, Robert A
- Chesworth, Richard
- Duncan, Kenneth W
Producer: 20150803
In:
Nature chemical biology vol. 11
Availability: No items available.
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56.
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Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. [electronic resource] by
- Thomenius, Michael J
- Totman, Jennifer
- Harvey, Darren
- Mitchell, Lorna H
- Riera, Thomas V
- Cosmopoulos, Kat
- Grassian, Alexandra R
- Klaus, Christine
- Foley, Megan
- Admirand, Elizabeth A
- Jahic, Haris
- Majer, Christina
- Wigle, Tim
- Jacques, Suzanne L
- Gureasko, Jodi
- Brach, Dorothy
- Lingaraj, Trupti
- West, Kip
- Smith, Sherri
- Rioux, Nathalie
- Waters, Nigel J
- Tang, Cuyue
- Raimondi, Alejandra
- Munchhof, Michael
- Mills, James E
- Ribich, Scott
- Porter Scott, Margaret
- Kuntz, Kevin W
- Janzen, William P
- Moyer, Mikel
- Smith, Jesse J
- Chesworth, Richard
- Copeland, Robert A
- Boriack-Sjodin, P Ann
Producer: 20181211
In:
PloS one vol. 13
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57.
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Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. [electronic resource] by
- Fedoriw, Andrew
- Rajapurkar, Satyajit R
- O'Brien, Shane
- Gerhart, Sarah V
- Mitchell, Lorna H
- Adams, Nicholas D
- Rioux, Nathalie
- Lingaraj, Trupti
- Ribich, Scott A
- Pappalardi, Melissa B
- Shah, Niyant
- Laraio, Jenny
- Liu, Yan
- Butticello, Michael
- Carpenter, Chris L
- Creasy, Caretha
- Korenchuk, Susan
- McCabe, Michael T
- McHugh, Charles F
- Nagarajan, Raman
- Wagner, Craig
- Zappacosta, Francesca
- Annan, Roland
- Concha, Nestor O
- Thomas, Roberta A
- Hart, Timothy K
- Smith, Jesse J
- Copeland, Robert A
- Moyer, Mikel P
- Campbell, John
- Stickland, Kim
- Mills, James
- Jacques-O'Hagan, Suzanne
- Allain, Christina
- Johnston, Danielle
- Raimondi, Alejandra
- Porter Scott, Margaret
- Waters, Nigel
- Swinger, Kerren
- Boriack-Sjodin, Ann
- Riera, Tom
- Shapiro, Gideon
- Chesworth, Richard
- Prinjha, Rabinder K
- Kruger, Ryan G
- Barbash, Olena
- Mohammad, Helai P
Producer: 20200330
In:
Cancer cell vol. 36
Availability: No items available.
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