Results
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41.
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Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping. [electronic resource] by
- Richardson, Christine M
- Nunns, Claire L
- Williamson, Douglas S
- Parratt, Martin J
- Dokurno, Pawel
- Howes, Rob
- Borgognoni, Jenifer
- Drysdale, Martin J
- Finch, Harry
- Hubbard, Roderick E
- Jackson, Philip S
- Kierstan, Peter
- Lentzen, Georg
- Moore, Jonathan D
- Murray, James B
- Simmonite, Heather
- Surgenor, Allan E
- Torrance, Christopher J
Producer: 20070924
In:
Bioorganic & medicinal chemistry letters vol. 17
Availability: No items available.
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42.
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Design and Synthesis of 56 Shape-Diverse 3D Fragments. [electronic resource] by
- Downes, Thomas D
- Jones, S Paul
- Klein, Hanna F
- Wheldon, Mary C
- Atobe, Masakazu
- Bond, Paul S
- Firth, James D
- Chan, Ngai S
- Waddelove, Laura
- Hubbard, Roderick E
- Blakemore, David C
- De Fusco, Claudia
- Roughley, Stephen D
- Vidler, Lewis R
- Whatton, Maria Ann
- Woolford, Alison J-A
- Wrigley, Gail L
- O'Brien, Peter
Producer: 20200722
In:
Chemistry (Weinheim an der Bergstrasse, Germany) vol. 26
Availability: No items available.
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43.
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Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1. [electronic resource] by
- Murray, James B
- Davidson, James
- Chen, Ijen
- Davis, Ben
- Dokurno, Pawel
- Graham, Christopher J
- Harris, Richard
- Jordan, Allan
- Matassova, Natalia
- Pedder, Christopher
- Ray, Stuart
- Roughley, Stephen D
- Smith, Julia
- Walmsley, Claire
- Wang, Yikang
- Whitehead, Neil
- Williamson, Douglas S
- Casara, Patrick
- Le Diguarher, Thierry
- Hickman, John
- Stark, Jerome
- Kotschy, András
- Geneste, Olivier
- Hubbard, Roderick E
Publication details: ACS omega May 2019
In:
ACS omega vol. 4
Availability: No items available.
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44.
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Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. [electronic resource] by
- Szlávik, Zoltan
- Ondi, Levente
- Csékei, Márton
- Paczal, Attila
- Szabó, Zoltán B
- Radics, Gábor
- Murray, James
- Davidson, James
- Chen, Ijen
- Davis, Ben
- Hubbard, Roderick E
- Pedder, Christopher
- Dokurno, Pawel
- Surgenor, Allan
- Smith, Julia
- Robertson, Alan
- LeToumelin-Braizat, Gaetane
- Cauquil, Nicolas
- Zarka, Marion
- Demarles, Didier
- Perron-Sierra, Francoise
- Claperon, Audrey
- Colland, Frederic
- Geneste, Olivier
- Kotschy, András
Producer: 20200610
In:
Journal of medicinal chemistry vol. 62
Availability: No items available.
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45.
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Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1). [electronic resource] by
- Williamson, Douglas S
- Smith, Garrick P
- Acheson-Dossang, Pamela
- Bedford, Simon T
- Chell, Victoria
- Chen, I-Jen
- Daechsel, Justus C A
- Daniels, Zoe
- David, Laurent
- Dokurno, Pawel
- Hentzer, Morten
- Herzig, Martin C
- Hubbard, Roderick E
- Moore, Jonathan D
- Murray, James B
- Newland, Samantha
- Ray, Stuart C
- Shaw, Terry
- Surgenor, Allan E
- Terry, Lindsey
- Thirstrup, Kenneth
- Wang, Yikang
- Christensen, Kenneth V
Producer: 20171122
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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46.
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Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. [electronic resource] by
- Sharp, Swee Y
- Prodromou, Chrisostomos
- Boxall, Kathy
- Powers, Marissa V
- Holmes, Joanna L
- Box, Gary
- Matthews, Thomas P
- Cheung, Kwai-Ming J
- Kalusa, Andrew
- James, Karen
- Hayes, Angela
- Hardcastle, Anthea
- Dymock, Brian
- Brough, Paul A
- Barril, Xavier
- Cansfield, Julie E
- Wright, Lisa
- Surgenor, Allan
- Foloppe, Nicolas
- Hubbard, Roderick E
- Aherne, Wynne
- Pearl, Laurence
- Jones, Keith
- McDonald, Edward
- Raynaud, Florence
- Eccles, Sue
- Drysdale, Martin
- Workman, Paul
Producer: 20070612
In:
Molecular cancer therapeutics vol. 6
Availability: No items available.
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47.
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Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone. [electronic resource] by
- Brough, Paul A
- Barril, Xavier
- Borgognoni, Jenifer
- Chene, Patrick
- Davies, Nicholas G M
- Davis, Ben
- Drysdale, Martin J
- Dymock, Brian
- Eccles, Suzanne A
- Garcia-Echeverria, Carlos
- Fromont, Christophe
- Hayes, Angela
- Hubbard, Roderick E
- Jordan, Allan M
- Jensen, Michael Rugaard
- Massey, Andrew
- Merrett, Angela
- Padfield, Antony
- Parsons, Rachel
- Radimerski, Thomas
- Raynaud, Florence I
- Robertson, Alan
- Roughley, Stephen D
- Schoepfer, Joseph
- Simmonite, Heather
- Sharp, Swee Y
- Surgenor, Allan
- Valenti, Melanie
- Walls, Steven
- Webb, Paul
- Wood, Mike
- Workman, Paul
- Wright, Lisa
Producer: 20090921
In:
Journal of medicinal chemistry vol. 52
Availability: No items available.
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48.
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NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. [electronic resource] by
- Eccles, Suzanne A
- Massey, Andy
- Raynaud, Florence I
- Sharp, Swee Y
- Box, Gary
- Valenti, Melanie
- Patterson, Lisa
- de Haven Brandon, Alexis
- Gowan, Sharon
- Boxall, Frances
- Aherne, Wynne
- Rowlands, Martin
- Hayes, Angela
- Martins, Vanessa
- Urban, Frederique
- Boxall, Kathy
- Prodromou, Chrisostomos
- Pearl, Laurence
- James, Karen
- Matthews, Thomas P
- Cheung, Kwai-Ming
- Kalusa, Andrew
- Jones, Keith
- McDonald, Edward
- Barril, Xavier
- Brough, Paul A
- Cansfield, Julie E
- Dymock, Brian
- Drysdale, Martin J
- Finch, Harry
- Howes, Rob
- Hubbard, Roderick E
- Surgenor, Alan
- Webb, Paul
- Wood, Mike
- Wright, Lisa
- Workman, Paul
Producer: 20080610
In:
Cancer research vol. 68
Availability: No items available.
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49.
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4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. [electronic resource] by
- Brough, Paul A
- Aherne, Wynne
- Barril, Xavier
- Borgognoni, Jenifer
- Boxall, Kathy
- Cansfield, Julie E
- Cheung, Kwai-Ming J
- Collins, Ian
- Davies, Nicholas G M
- Drysdale, Martin J
- Dymock, Brian
- Eccles, Suzanne A
- Finch, Harry
- Fink, Alexandra
- Hayes, Angela
- Howes, Robert
- Hubbard, Roderick E
- James, Karen
- Jordan, Allan M
- Lockie, Andrea
- Martins, Vanessa
- Massey, Andrew
- Matthews, Thomas P
- McDonald, Edward
- Northfield, Christopher J
- Pearl, Laurence H
- Prodromou, Chrisostomos
- Ray, Stuart
- Raynaud, Florence I
- Roughley, Stephen D
- Sharp, Swee Y
- Surgenor, Allan
- Walmsley, D Lee
- Webb, Paul
- Wood, Mike
- Workman, Paul
- Wright, Lisa
Producer: 20080417
In:
Journal of medicinal chemistry vol. 51
Availability: No items available.
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