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	21.	Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. [electronic resource] by Howard, Nigel Abell, Chris Blakemore, Wendy Chessari, Gianni Congreve, Miles Howard, Steven Jhoti, Harren Murray, Christopher W Seavers, Lisa C A van Montfort, Rob L M Producer: 20060410 In: Journal of medicinal chemistry vol. 49 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	22.	Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay. [electronic resource] by Newbatt, Yvette Hardcastle, Anthea McAndrew, P Craig Strover, Jade A Mirza, Amin Morgan, Gareth J Burke, Rosemary Davies, Faith E Collins, Ian van Montfort, Rob L M Producer: 20131118 In: Journal of biomolecular screening vol. 18 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	23.	Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70. [electronic resource] by Cheeseman, Matthew D Westwood, Isaac M Barbeau, Olivier Rowlands, Martin Dobson, Sarah Jones, Alan M Jeganathan, Fiona Burke, Rosemary Kadi, Nadia Workman, Paul Collins, Ian van Montfort, Rob L M Jones, Keith Producer: 20170529 In: Journal of medicinal chemistry vol. 59 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	24.	Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. [electronic resource] by Gurden, Mark D Westwood, Isaac M Faisal, Amir Naud, Sébastien Cheung, Kwai-Ming J McAndrew, Craig Wood, Amy Schmitt, Jessica Boxall, Kathy Mak, Grace Workman, Paul Burke, Rosemary Hoelder, Swen Blagg, Julian Van Montfort, Rob L M Linardopoulos, Spiros Producer: 20151124 In: Cancer research vol. 75 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	25.	Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. [electronic resource] by Whelligan, Daniel K Solanki, Savade Taylor, Dawn Thomson, Douglas W Cheung, Kwai-Ming J Boxall, Kathy Mas-Droux, Corine Barillari, Caterina Burns, Samantha Grummitt, Charles G Collins, Ian van Montfort, Rob L M Aherne, G Wynne Bayliss, Richard Hoelder, Swen Producer: 20101228 In: Journal of medicinal chemistry vol. 53 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	26.	Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2. [electronic resource] by Silva-Santisteban, M Cris Westwood, Isaac M Boxall, Kathy Brown, Nathan Peacock, Sam McAndrew, Craig Barrie, Elaine Richards, Meirion Mirza, Amin Oliver, Antony W Burke, Rosemary Hoelder, Swen Jones, Keith Aherne, G Wynne Blagg, Julian Collins, Ian Garrett, Michelle D van Montfort, Rob L M Producer: 20140123 In: PloS one vol. 8 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	27.	A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. [electronic resource] by Jones, Alan M Westwood, Isaac M Osborne, James D Matthews, Thomas P Cheeseman, Matthew D Rowlands, Martin G Jeganathan, Fiona Burke, Rosemary Lee, Diane Kadi, Nadia Liu, Manjuan Richards, Meirion McAndrew, Craig Yahya, Norhakim Dobson, Sarah E Jones, Keith Workman, Paul Collins, Ian van Montfort, Rob L M Producer: 20180619 In: Scientific reports vol. 6 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	28.	The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. [electronic resource] by Couty, Sylvain Westwood, Isaac M Kalusa, Andrew Cano, Celine Travers, Jon Boxall, Kathy Chow, Chiau Ling Burns, Sam Schmitt, Jessica Pickard, Lisa Barillari, Caterina McAndrew, P Craig Clarke, Paul A Linardopoulos, Spiros Griffin, Roger J Aherne, G Wynne Raynaud, Florence I Workman, Paul Jones, Keith van Montfort, Rob L M Producer: 20140722 In: Oncotarget vol. 4 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	29.	Privileged Structures and Polypharmacology within and between Protein Families. [electronic resource] by Meyers, Joshua Chessum, Nicola E A Ali, Salyha Mok, N Yi Wilding, Birgit Pasqua, A Elisa Rowlands, Martin Tucker, Michael J Evans, Lindsay E Rye, Carl S O'Fee, Lisa Le Bihan, Yann-Vaï Burke, Rosemary Carter, Michael Workman, Paul Blagg, Julian Brown, Nathan van Montfort, Rob L M Jones, Keith Cheeseman, Matthew D Publication details: ACS medicinal chemistry letters Dec 2018 In: ACS medicinal chemistry letters vol. 9 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	30.	High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers. [electronic resource] by Anderhub, Simon J Mak, Grace Wing-Yan Gurden, Mark D Faisal, Amir Drosopoulos, Konstantinos Walsh, Katie Woodward, Hannah L Innocenti, Paolo Westwood, Isaac M Naud, Sébastien Hayes, Angela Theofani, Efthymia Filosto, Simone Saville, Harry Burke, Rosemary van Montfort, Rob L M Raynaud, Florence I Blagg, Julian Hoelder, Swen Eccles, Suzanne A Linardopoulos, Spiros Producer: 20200609 In: Molecular cancer therapeutics vol. 18 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	31.	Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives. [electronic resource] by Tisi, Dominic Chiarparin, Elisabetta Tamanini, Emiliano Pathuri, Puja Coyle, Joseph E Hold, Adam Holding, Finn P Amin, Nader Martin, Agnes C L Rich, Sharna J Berdini, Valerio Yon, Jeff Acklam, Paul Burke, Rosemary Drouin, Ludovic Harmer, Jenny E Jeganathan, Fiona van Montfort, Rob L M Newbatt, Yvette Tortorici, Marcello Westlake, Maura Wood, Amy Hoelder, Swen Heightman, Tom D Producer: 20170622 In: ACS chemical biology vol. 11 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	32.	Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. [electronic resource] by Cheeseman, Matthew D Chessum, Nicola E A Rye, Carl S Pasqua, A Elisa Tucker, Michael J Wilding, Birgit Evans, Lindsay E Lepri, Susan Richards, Meirion Sharp, Swee Y Ali, Salyha Rowlands, Martin O'Fee, Lisa Miah, Asadh Hayes, Angela Henley, Alan T Powers, Marissa Te Poele, Robert De Billy, Emmanuel Pellegrino, Loredana Raynaud, Florence Burke, Rosemary van Montfort, Rob L M Eccles, Suzanne A Workman, Paul Jones, Keith Producer: 20170807 In: Journal of medicinal chemistry vol. 60 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	33.	Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). [electronic resource] by Naud, Sébastien Westwood, Isaac M Faisal, Amir Sheldrake, Peter Bavetsias, Vassilios Atrash, Butrus Cheung, Kwai-Ming J Liu, Manjuan Hayes, Angela Schmitt, Jessica Wood, Amy Choi, Vanessa Boxall, Kathy Mak, Grace Gurden, Mark Valenti, Melanie de Haven Brandon, Alexis Henley, Alan Baker, Ross McAndrew, Craig Matijssen, Berry Burke, Rosemary Hoelder, Swen Eccles, Suzanne A Raynaud, Florence I Linardopoulos, Spiros van Montfort, Rob L M Blagg, Julian Producer: 20140304 In: Journal of medicinal chemistry vol. 56 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	34.	Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach. [electronic resource] by Innocenti, Paolo Woodward, Hannah L Solanki, Savade Naud, Sébastien Westwood, Isaac M Cronin, Nora Hayes, Angela Roberts, Jennie Henley, Alan T Baker, Ross Faisal, Amir Mak, Grace Wing-Yan Box, Gary Valenti, Melanie De Haven Brandon, Alexis O'Fee, Lisa Saville, Harry Schmitt, Jessica Matijssen, Berry Burke, Rosemary van Montfort, Rob L M Raynaud, Florence I Eccles, Suzanne A Linardopoulos, Spiros Blagg, Julian Hoelder, Swen Producer: 20170718 In: Journal of medicinal chemistry vol. 59 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	35.	Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N [electronic resource] by Woodward, Hannah L Innocenti, Paolo Cheung, Kwai-Ming J Hayes, Angela Roberts, Jennie Henley, Alan T Faisal, Amir Mak, Grace Wing-Yan Box, Gary Westwood, Isaac M Cronin, Nora Carter, Michael Valenti, Melanie De Haven Brandon, Alexis O'Fee, Lisa Saville, Harry Schmitt, Jessica Burke, Rosemary Broccatelli, Fabio van Montfort, Rob L M Raynaud, Florence I Eccles, Suzanne A Linardopoulos, Spiros Blagg, Julian Hoelder, Swen Producer: 20191014 In: Journal of medicinal chemistry vol. 61 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	36.	C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. [electronic resource] by Le Bihan, Yann-Vaï Lanigan, Rachel M Atrash, Butrus McLaughlin, Mark G Velupillai, Srikannathasan Malcolm, Andrew G England, Katherine S Ruda, Gian Filippo Mok, N Yi Tumber, Anthony Tomlin, Kathy Saville, Harry Shehu, Erald McAndrew, Craig Carmichael, LeAnne Bennett, James M Jeganathan, Fiona Eve, Paul Donovan, Adam Hayes, Angela Wood, Francesca Raynaud, Florence I Fedorov, Oleg Brennan, Paul E Burke, Rosemary van Montfort, Rob L M Rossanese, Olivia W Blagg, Julian Bavetsias, Vassilios Producer: 20190725 In: European journal of medicinal chemistry vol. 177 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	37.	Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. [electronic resource] by Reader, John C Matthews, Thomas P Klair, Suki Cheung, Kwai-Ming J Scanlon, Jane Proisy, Nicolas Addison, Glynn Ellard, John Piton, Nelly Taylor, Suzanne Cherry, Michael Fisher, Martin Boxall, Kathy Burns, Samantha Walton, Michael I Westwood, Isaac M Hayes, Angela Eve, Paul Valenti, Melanie de Haven Brandon, Alexis Box, Gary van Montfort, Rob L M Williams, David H Aherne, G Wynne Raynaud, Florence I Eccles, Suzanne A Garrett, Michelle D Collins, Ian Producer: 20120308 In: Journal of medicinal chemistry vol. 54 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	38.	Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). [electronic resource] by Osborne, James D Matthews, Thomas P McHardy, Tatiana Proisy, Nicolas Cheung, Kwai-Ming J Lainchbury, Michael Brown, Nathan Walton, Michael I Eve, Paul D Boxall, Katherine J Hayes, Angela Henley, Alan T Valenti, Melanie R De Haven Brandon, Alexis K Box, Gary Jamin, Yann Robinson, Simon P Westwood, Isaac M van Montfort, Rob L M Leonard, Philip M Lamers, Marieke B A C Reader, John C Aherne, G Wynne Raynaud, Florence I Eccles, Suzanne A Garrett, Michelle D Collins, Ian Producer: 20170606 In: Journal of medicinal chemistry vol. 59 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	39.	Achieving [electronic resource] by Bellenie, Benjamin R Cheung, Kwai-Ming J Varela, Ana Pierrat, Olivier A Collie, Gavin W Box, Gary M Bright, Michael D Gowan, Sharon Hayes, Angela Rodrigues, Matthew J Shetty, Kartika N Carter, Michael Davis, Owen A Henley, Alan T Innocenti, Paolo Johnson, Louise D Liu, Manjuan de Klerk, Selby Le Bihan, Yann-Vaï Lloyd, Matthew G McAndrew, P Craig Shehu, Erald Talbot, Rachel Woodward, Hannah L Burke, Rosemary Kirkin, Vladimir van Montfort, Rob L M Raynaud, Florence I Rossanese, Olivia W Hoelder, Swen Producer: 20200924 In: Journal of medicinal chemistry vol. 63 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	40.	8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. [electronic resource] by Bavetsias, Vassilios Lanigan, Rachel M Ruda, Gian Filippo Atrash, Butrus McLaughlin, Mark G Tumber, Anthony Mok, N Yi Le Bihan, Yann-Vaï Dempster, Sally Boxall, Katherine J Jeganathan, Fiona Hatch, Stephanie B Savitsky, Pavel Velupillai, Srikannathasan Krojer, Tobias England, Katherine S Sejberg, Jimmy Thai, Ching Donovan, Adam Pal, Akos Scozzafava, Giuseppe Bennett, James M Kawamura, Akane Johansson, Catrine Szykowska, Aleksandra Gileadi, Carina Burgess-Brown, Nicola A von Delft, Frank Oppermann, Udo Walters, Zoe Shipley, Janet Raynaud, Florence I Westaway, Susan M Prinjha, Rab K Fedorov, Oleg Burke, Rosemary Schofield, Christopher J Westwood, Isaac M Bountra, Chas Müller, Susanne van Montfort, Rob L M Brennan, Paul E Blagg, Julian Producer: 20160726 In: Journal of medicinal chemistry vol. 59 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)

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