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21.
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The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. [electronic resource] by
- Cheung, Kwai-Ming J
- Matthews, Thomas P
- James, Karen
- Rowlands, Martin G
- Boxall, Katherine J
- Sharp, Swee Y
- Maloney, Alison
- Roe, S Mark
- Prodromou, Chrisostomos
- Pearl, Laurence H
- Aherne, G Wynne
- McDonald, Edward
- Workman, Paul
Producer: 20051219
In:
Bioorganic & medicinal chemistry letters vol. 15
Availability: No items available.
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22.
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Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms. [electronic resource] by
- Wright, Lisa
- Barril, Xavier
- Dymock, Brian
- Sheridan, Louisa
- Surgenor, Allan
- Beswick, Mandy
- Drysdale, Martin
- Collier, Adam
- Massey, Andy
- Davies, Nick
- Fink, Alex
- Fromont, Christophe
- Aherne, Wynne
- Boxall, Kathy
- Sharp, Swee
- Workman, Paul
- Hubbard, Roderick E
Producer: 20050103
In:
Chemistry & biology vol. 11
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23.
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Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766). [electronic resource] by
- Chessum, Nicola E A
- Sharp, Swee Y
- Caldwell, John J
- Pasqua, A Elisa
- Wilding, Birgit
- Colombano, Giampiero
- Collins, Ian
- Ozer, Bugra
- Richards, Meirion
- Rowlands, Martin
- Stubbs, Mark
- Burke, Rosemary
- McAndrew, P Craig
- Clarke, Paul A
- Workman, Paul
- Cheeseman, Matthew D
- Jones, Keith
Producer: 20190225
In:
Journal of medicinal chemistry vol. 61
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24.
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Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin. [electronic resource] by
- Maloney, Alison
- Clarke, Paul A
- Naaby-Hansen, Soren
- Stein, Rob
- Koopman, Jens-Oliver
- Akpan, Akunna
- Yang, Alice
- Zvelebil, Marketa
- Cramer, Rainer
- Stimson, Lindsay
- Aherne, Wynne
- Banerji, Udai
- Judson, Ian
- Sharp, Swee
- Powers, Marissa
- deBilly, Emmanuel
- Salmons, Joanne
- Walton, Michael
- Burlingame, Al
- Waterfield, Michael
- Workman, Paul
Producer: 20070509
In:
Cancer research vol. 67
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25.
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Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor. [electronic resource] by
- Whittaker, Steven R
- Barlow, Clare
- Martin, Mathew P
- Mancusi, Caterina
- Wagner, Steve
- Self, Annette
- Barrie, Elaine
- Te Poele, Robert
- Sharp, Swee
- Brown, Nathan
- Wilson, Stuart
- Jackson, Wayne
- Fischer, Peter M
- Clarke, Paul A
- Walton, Michael I
- McDonald, Edward
- Blagg, Julian
- Noble, Martin
- Garrett, Michelle D
- Workman, Paul
Producer: 20190218
In:
Molecular oncology vol. 12
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26.
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The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers. [electronic resource] by
- Noel, Elodie E
- Yeste-Velasco, Marc
- Mao, Xueying
- Perry, Jackie
- Kudahetti, Sakunthala C
- Li, Ningfeng F
- Sharp, Swee
- Chaplin, Tracy
- Xue, Liyan
- McIntyre, Alan
- Shan, Ling
- Powles, Thomas
- Oliver, R Tim D
- Young, Bryan D
- Shipley, Janet
- Berney, Daniel M
- Joel, Simon P
- Lu, Yong-Jie
Producer: 20101004
In:
The American journal of pathology vol. 176
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27.
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Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells. [electronic resource] by
- Ferraldeschi, Roberta
- Welti, Jonathan
- Powers, Marissa V
- Yuan, Wei
- Smyth, Tomoko
- Seed, George
- Riisnaes, Ruth
- Hedayat, Somaieh
- Wang, Hannah
- Crespo, Mateus
- Nava Rodrigues, Daniel
- Figueiredo, Ines
- Miranda, Susana
- Carreira, Suzanne
- Lyons, John F
- Sharp, Swee
- Plymate, Stephen R
- Attard, Gerhardt
- Wallis, Nicola
- Workman, Paul
- de Bono, Johann S
Producer: 20170724
In:
Cancer research vol. 76
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28.
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EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines. [electronic resource] by
- Bax, Dorine A
- Gaspar, Nathalie
- Little, Suzanne E
- Marshall, Lynley
- Perryman, Lara
- Regairaz, Marie
- Viana-Pereira, Marta
- Vuononvirta, Raisa
- Sharp, Swee Y
- Reis-Filho, Jorge S
- Stávale, João N
- Al-Sarraj, Safa
- Reis, Rui M
- Vassal, Gilles
- Pearson, Andrew D J
- Hargrave, Darren
- Ellison, David W
- Workman, Paul
- Jones, Chris
Producer: 20100330
In:
Clinical cancer research : an official journal of the American Association for Cancer Research vol. 15
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29.
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Correction: [electronic resource] by
- Sharp, Swee Y
- Boxall, Kathy
- Rowlands, Martin
- Prodromou, Chrisostomos
- Roe, S Mark
- Maloney, Alison
- Powers, Marissa
- Clarke, Paul A
- Box, Gary
- Sanderson, Sharon
- Patterson, Lisa
- Matthews, Thomas P
- Cheung, Kwai-Ming J
- Ball, Karen
- Hayes, Angela
- Raynaud, Florence
- Marais, Richard
- Pearl, Laurence
- Eccles, Sue
- Aherne, Wynne
- McDonald, Edward
- Workman, Paul
Publication details: Cancer research Jan 2019
In:
Cancer research vol. 79
Availability: No items available.
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30.
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In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. [electronic resource] by
- Sharp, Swee Y
- Boxall, Kathy
- Rowlands, Martin
- Prodromou, Chrisostomos
- Roe, S Mark
- Maloney, Alison
- Powers, Marissa
- Clarke, Paul A
- Box, Gary
- Sanderson, Sharon
- Patterson, Lisa
- Matthews, Thomas P
- Cheung, Kwai-Ming J
- Ball, Karen
- Hayes, Angela
- Raynaud, Florence
- Marais, Richard
- Pearl, Laurence
- Eccles, Sue
- Aherne, Wynne
- McDonald, Edward
- Workman, Paul
Producer: 20070412
In:
Cancer research vol. 67
Availability: No items available.
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31.
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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9. [electronic resource] by
- Rye, Carl S
- Chessum, Nicola E A
- Lamont, Scott
- Pike, Kurt G
- Faulder, Paul
- Demeritt, Julie
- Kemmitt, Paul
- Tucker, Julie
- Zani, Lorenzo
- Cheeseman, Matthew D
- Isaac, Rosie
- Goodwin, Louise
- Boros, Joanna
- Raynaud, Florence
- Hayes, Angela
- Henley, Alan T
- de Billy, Emmanuel
- Lynch, Christopher J
- Sharp, Swee Y
- Te Poele, Robert
- Fee, Lisa O'
- Foote, Kevin M
- Green, Stephen
- Workman, Paul
- Jones, Keith
Publication details: MedChemComm Aug 2016
In:
MedChemComm vol. 7
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32.
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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. [electronic resource] by
- Cheeseman, Matthew D
- Chessum, Nicola E A
- Rye, Carl S
- Pasqua, A Elisa
- Tucker, Michael J
- Wilding, Birgit
- Evans, Lindsay E
- Lepri, Susan
- Richards, Meirion
- Sharp, Swee Y
- Ali, Salyha
- Rowlands, Martin
- O'Fee, Lisa
- Miah, Asadh
- Hayes, Angela
- Henley, Alan T
- Powers, Marissa
- Te Poele, Robert
- De Billy, Emmanuel
- Pellegrino, Loredana
- Raynaud, Florence
- Burke, Rosemary
- van Montfort, Rob L M
- Eccles, Suzanne A
- Workman, Paul
- Jones, Keith
Producer: 20170807
In:
Journal of medicinal chemistry vol. 60
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33.
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Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. [electronic resource] by
- Sharp, Swee Y
- Prodromou, Chrisostomos
- Boxall, Kathy
- Powers, Marissa V
- Holmes, Joanna L
- Box, Gary
- Matthews, Thomas P
- Cheung, Kwai-Ming J
- Kalusa, Andrew
- James, Karen
- Hayes, Angela
- Hardcastle, Anthea
- Dymock, Brian
- Brough, Paul A
- Barril, Xavier
- Cansfield, Julie E
- Wright, Lisa
- Surgenor, Allan
- Foloppe, Nicolas
- Hubbard, Roderick E
- Aherne, Wynne
- Pearl, Laurence
- Jones, Keith
- McDonald, Edward
- Raynaud, Florence
- Eccles, Sue
- Drysdale, Martin
- Workman, Paul
Producer: 20070612
In:
Molecular cancer therapeutics vol. 6
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34.
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Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone. [electronic resource] by
- Brough, Paul A
- Barril, Xavier
- Borgognoni, Jenifer
- Chene, Patrick
- Davies, Nicholas G M
- Davis, Ben
- Drysdale, Martin J
- Dymock, Brian
- Eccles, Suzanne A
- Garcia-Echeverria, Carlos
- Fromont, Christophe
- Hayes, Angela
- Hubbard, Roderick E
- Jordan, Allan M
- Jensen, Michael Rugaard
- Massey, Andrew
- Merrett, Angela
- Padfield, Antony
- Parsons, Rachel
- Radimerski, Thomas
- Raynaud, Florence I
- Robertson, Alan
- Roughley, Stephen D
- Schoepfer, Joseph
- Simmonite, Heather
- Sharp, Swee Y
- Surgenor, Allan
- Valenti, Melanie
- Walls, Steven
- Webb, Paul
- Wood, Mike
- Workman, Paul
- Wright, Lisa
Producer: 20090921
In:
Journal of medicinal chemistry vol. 52
Availability: No items available.
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35.
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NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. [electronic resource] by
- Eccles, Suzanne A
- Massey, Andy
- Raynaud, Florence I
- Sharp, Swee Y
- Box, Gary
- Valenti, Melanie
- Patterson, Lisa
- de Haven Brandon, Alexis
- Gowan, Sharon
- Boxall, Frances
- Aherne, Wynne
- Rowlands, Martin
- Hayes, Angela
- Martins, Vanessa
- Urban, Frederique
- Boxall, Kathy
- Prodromou, Chrisostomos
- Pearl, Laurence
- James, Karen
- Matthews, Thomas P
- Cheung, Kwai-Ming
- Kalusa, Andrew
- Jones, Keith
- McDonald, Edward
- Barril, Xavier
- Brough, Paul A
- Cansfield, Julie E
- Dymock, Brian
- Drysdale, Martin J
- Finch, Harry
- Howes, Rob
- Hubbard, Roderick E
- Surgenor, Alan
- Webb, Paul
- Wood, Mike
- Wright, Lisa
- Workman, Paul
Producer: 20080610
In:
Cancer research vol. 68
Availability: No items available.
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36.
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4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. [electronic resource] by
- Brough, Paul A
- Aherne, Wynne
- Barril, Xavier
- Borgognoni, Jenifer
- Boxall, Kathy
- Cansfield, Julie E
- Cheung, Kwai-Ming J
- Collins, Ian
- Davies, Nicholas G M
- Drysdale, Martin J
- Dymock, Brian
- Eccles, Suzanne A
- Finch, Harry
- Fink, Alexandra
- Hayes, Angela
- Howes, Robert
- Hubbard, Roderick E
- James, Karen
- Jordan, Allan M
- Lockie, Andrea
- Martins, Vanessa
- Massey, Andrew
- Matthews, Thomas P
- McDonald, Edward
- Northfield, Christopher J
- Pearl, Laurence H
- Prodromou, Chrisostomos
- Ray, Stuart
- Raynaud, Florence I
- Roughley, Stephen D
- Sharp, Swee Y
- Surgenor, Allan
- Walmsley, D Lee
- Webb, Paul
- Wood, Mike
- Workman, Paul
- Wright, Lisa
Producer: 20080417
In:
Journal of medicinal chemistry vol. 51
Availability: No items available.
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