Results
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21.
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Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold. [electronic resource] by
- Schwertz, Geoffrey
- Witschel, Matthias C
- Rottmann, Matthias
- Leartsakulpanich, Ubolsree
- Chitnumsub, Penchit
- Jaruwat, Aritsara
- Amornwatcharapong, Watcharee
- Ittarat, Wanwipa
- Schäfer, Anja
- Aponte, Raphael A
- Trapp, Nils
- Chaiyen, Pimchai
- Diederich, François
Producer: 20190424
In:
ChemMedChem vol. 13
Availability: No items available.
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22.
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Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model. [electronic resource] by
- Lakshminarayana, Suresh B
- Freymond, Céline
- Fischli, Christoph
- Yu, Jing
- Weber, Sebastian
- Goh, Anne
- Yeung, Bryan K S
- Ho, Paul C
- Dartois, Véronique
- Diagana, Thierry T
- Rottmann, Matthias
- Blasco, Francesca
Producer: 20151019
In:
Antimicrobial agents and chemotherapy vol. 59
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23.
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Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs. [electronic resource] by
- Schwertz, Geoffrey
- Frei, Michelle S
- Witschel, Matthias C
- Rottmann, Matthias
- Leartsakulpanich, Ubolsree
- Chitnumsub, Penchit
- Jaruwat, Aritsara
- Ittarat, Wanwipa
- Schäfer, Anja
- Aponte, Raphael A
- Trapp, Nils
- Mark, Kerstin
- Chaiyen, Pimchai
- Diederich, François
Producer: 20180207
In:
Chemistry (Weinheim an der Bergstrasse, Germany) vol. 23
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24.
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Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. [electronic resource] by
- Reker, Daniel
- Seet, Michael
- Pillong, Max
- Koch, Christian P
- Schneider, Petra
- Witschel, Matthias C
- Rottmann, Matthias
- Freymond, Céline
- Brun, Reto
- Schweizer, Bernd
- Illarionov, Boris
- Bacher, Adelbert
- Fischer, Markus
- Diederich, François
- Schneider, Gisbert
Producer: 20151112
In:
Angewandte Chemie (International ed. in English) vol. 53
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25.
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Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii. [electronic resource] by
- Kemp, Louise E
- Rusch, Marion
- Adibekian, Alexander
- Bullen, Hayley E
- Graindorge, Arnault
- Freymond, Céline
- Rottmann, Matthias
- Braun-Breton, Catherine
- Baumeister, Stefan
- Porfetye, Arthur T
- Vetter, Ingrid R
- Hedberg, Christian
- Soldati-Favre, Dominique
Producer: 20131126
In:
The Journal of biological chemistry vol. 288
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26.
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Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates. [electronic resource] by
- Mombelli, Paolo
- Witschel, Matthias C
- van Zijl, Anthoni W
- Geist, Julie G
- Rottmann, Matthias
- Freymond, Céline
- Röhl, Franz
- Kaiser, Marcel
- Illarionova, Victoria
- Fischer, Markus
- Siepe, Isabella
- Schweizer, W Bernd
- Brun, Reto
- Diederich, François
Producer: 20120417
In:
ChemMedChem vol. 7
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27.
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Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure-Activity Relationship Studies, and Biological Assessment. [electronic resource] by
- Mueller, Rudolf
- Reddy, Virsinha
- Nchinda, Aloysius T
- Mebrahtu, Fanuel
- Taylor, Dale
- Lawrence, Nina
- Tanner, Lloyd
- Barnabe, Marine
- Eyermann, Charles J
- Zou, Bin
- Kondreddi, Ravinder R
- Lakshminarayana, Suresh B
- Rottmann, Matthias
- Street, Leslie J
- Chibale, Kelly
Publication details: ACS omega Mar 2020
In:
ACS omega vol. 5
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28.
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Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action. [electronic resource] by
- Bürstner, Nathalie
- Roggo, Silvio
- Ostermann, Nils
- Blank, Jutta
- Delmas, Cecile
- Freuler, Felix
- Gerhartz, Bernd
- Hinniger, Alexandra
- Hoepfner, Dominic
- Liechty, Brigitta
- Mihalic, Manuel
- Murphy, Jason
- Pistorius, Dominik
- Rottmann, Matthias
- Thomas, Jason R
- Schirle, Markus
- Schmitt, Esther K
Producer: 20161011
In:
Chembiochem : a European journal of chemical biology vol. 16
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29.
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Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting [electronic resource] by
- Arez, Francisca
- Rebelo, Sofia P
- Fontinha, Diana
- Simão, Daniel
- Martins, Tatiana R
- Machado, Marta
- Fischli, Christoph
- Oeuvray, Claude
- Badolo, Lassina
- Carrondo, Manuel J T
- Rottmann, Matthias
- Spangenberg, Thomas
- Brito, Catarina
- Greco, Beatrice
- Prudêncio, Miguel
- Alves, Paula M
Producer: 20200708
In:
ACS infectious diseases vol. 5
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30.
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Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. [electronic resource] by
- Chadwick, James
- Amewu, Richard K
- Marti, Francesc
- Garah, Fatima Bousejra-El
- Sharma, Raman
- Berry, Neil G
- Stocks, Paul A
- Burrell-Saward, Hollie
- Wittlin, Sergio
- Rottmann, Matthias
- Brun, Reto
- Taramelli, Donatella
- Parapini, Silvia
- Ward, Stephen A
- O'Neill, Paul M
Producer: 20111128
In:
ChemMedChem vol. 6
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31.
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The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System. [electronic resource] by
- Zobeiri, Mehrnoush
- Chaudhary, Rahul
- Blaich, Anne
- Rottmann, Matthias
- Herrmann, Stefan
- Meuth, Patrick
- Bista, Pawan
- Kanyshkova, Tatyana
- Lüttjohann, Annika
- Narayanan, Venu
- Hundehege, Petra
- Meuth, Sven G
- Romanelli, Maria Novella
- Urbano, Francisco J
- Pape, Hans-Christian
- Budde, Thomas
- Ludwig, Andreas
Producer: 20200716
In:
Cerebral cortex (New York, N.Y. : 1991) vol. 29
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32.
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Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures. [electronic resource] by
- Schwertz, Geoffrey
- Witschel, Matthias C
- Rottmann, Matthias
- Bonnert, Roger
- Leartsakulpanich, Ubolsree
- Chitnumsub, Penchit
- Jaruwat, Aritsara
- Ittarat, Wanwipa
- Schäfer, Anja
- Aponte, Raphael A
- Charman, Susan A
- White, Karen L
- Kundu, Abhijit
- Sadhukhan, Surajit
- Lloyd, Mel
- Freiberg, Gail M
- Srikumaran, Myron
- Siggel, Marc
- Zwyssig, Adrian
- Chaiyen, Pimchai
- Diederich, François
Producer: 20170811
In:
Journal of medicinal chemistry vol. 60
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33.
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Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. [electronic resource] by
- Nzila, Alexis
- Rottmann, Matthias
- Chitnumsub, Penchit
- Kiara, Stevens M
- Kamchonwongpaisan, Sumalee
- Maneeruttanarungroj, Cherdsak
- Taweechai, Supannee
- Yeung, Bryan K S
- Goh, Anne
- Lakshminarayana, Suresh B
- Zou, Bin
- Wong, Josephine
- Ma, Ngai Ling
- Weaver, Margaret
- Keller, Thomas H
- Dartois, Veronique
- Wittlin, Sergio
- Brun, Reto
- Yuthavong, Yongyuth
- Diagana, Thierry T
Producer: 20100914
In:
Antimicrobial agents and chemotherapy vol. 54
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34.
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Malaria-infected mice are cured by oral administration of new artemisinin derivatives. [electronic resource] by
- Posner, Gary H
- Chang, Wonsuk
- Hess, Lindsey
- Woodard, Lauren
- Sinishtaj, Sandra
- Usera, Aimee R
- Maio, William
- Rosenthal, Andrew S
- Kalinda, Alvin S
- D'Angelo, John G
- Petersen, Kimberly S
- Stohler, Remo
- Chollet, Jacques
- Santo-Tomas, Josefina
- Snyder, Christopher
- Rottmann, Matthias
- Wittlin, Sergio
- Brun, Reto
- Shapiro, Theresa A
Producer: 20080519
In:
Journal of medicinal chemistry vol. 51
Availability: No items available.
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35.
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Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs. [electronic resource] by
- Martí Coma-Cros, Elisabet
- Biosca, Arnau
- Marques, Joana
- Carol, Laura
- Urbán, Patricia
- Berenguer, Diana
- Riera, Maria Cristina
- Delves, Michael
- Sinden, Robert E
- Valle-Delgado, Juan José
- Spanos, Lefteris
- Siden-Kiamos, Inga
- Pérez, Paula
- Paaijmans, Krijn
- Rottmann, Matthias
- Manfredi, Amedea
- Ferruti, Paolo
- Ranucci, Elisabetta
- Fernàndez-Busquets, Xavier
Publication details: Pharmaceutics Nov 2018
In:
Pharmaceutics vol. 10
Availability: No items available.
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36.
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Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. [electronic resource] by
- Gemma, Sandra
- Campiani, Giuseppe
- Butini, Stefania
- Joshi, Bhupendra P
- Kukreja, Gagan
- Coccone, Salvatore Sanna
- Bernetti, Matteo
- Persico, Marco
- Nacci, Vito
- Fiorini, Isabella
- Novellino, Ettore
- Taramelli, Donatella
- Basilico, Nicoletta
- Parapini, Silvia
- Yardley, Vanessa
- Croft, Simon
- Keller-Maerki, Sonja
- Rottmann, Matthias
- Brun, Reto
- Coletta, Massimiliano
- Marini, Stefano
- Guiso, Giovanna
- Caccia, Silvio
- Fattorusso, Caterina
Producer: 20090223
In:
Journal of medicinal chemistry vol. 52
Availability: No items available.
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37.
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Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities. [electronic resource] by
- Witschel, Matthias C
- Rottmann, Matthias
- Schwab, Anatol
- Leartsakulpanich, Ubolsree
- Chitnumsub, Penchit
- Seet, Michael
- Tonazzi, Sandro
- Schwertz, Geoffrey
- Stelzer, Frank
- Mietzner, Thomas
- McNamara, Case
- Thater, Frank
- Freymond, Céline
- Jaruwat, Aritsara
- Pinthong, Chatchadaporn
- Riangrungroj, Pinpunya
- Oufir, Mouhssin
- Hamburger, Matthias
- Mäser, Pascal
- Sanz-Alonso, Laura M
- Charman, Susan
- Wittlin, Sergio
- Yuthavong, Yongyuth
- Chaiyen, Pimchai
- Diederich, François
Producer: 20150630
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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38.
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Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. [electronic resource] by
- Gemma, Sandra
- Camodeca, Caterina
- Sanna Coccone, Salvatore
- Joshi, Bhupendra P
- Bernetti, Matteo
- Moretti, Vittoria
- Brogi, Simone
- Bonache de Marcos, Maria Cruz
- Savini, Luisa
- Taramelli, Donatella
- Basilico, Nicoletta
- Parapini, Silvia
- Rottmann, Matthias
- Brun, Reto
- Lamponi, Stefania
- Caccia, Silvio
- Guiso, Giovanna
- Summers, Robert L
- Martin, Rowena E
- Saponara, Simona
- Gorelli, Beatrice
- Novellino, Ettore
- Campiani, Giuseppe
- Butini, Stefania
Producer: 20121105
In:
Journal of medicinal chemistry vol. 55
Availability: No items available.
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39.
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Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria. [electronic resource] by
- Yeung, Bryan K S
- Zou, Bin
- Rottmann, Matthias
- Lakshminarayana, Suresh B
- Ang, Shi Hua
- Leong, Seh Yong
- Tan, Jocelyn
- Wong, Josephine
- Keller-Maerki, Sonja
- Fischli, Christoph
- Goh, Anne
- Schmitt, Esther K
- Krastel, Philipp
- Francotte, Eric
- Kuhen, Kelli
- Plouffe, David
- Henson, Kerstin
- Wagner, Trixie
- Winzeler, Elizabeth A
- Petersen, Frank
- Brun, Reto
- Dartois, Veronique
- Diagana, Thierry T
- Keller, Thomas H
Producer: 20100825
In:
Journal of medicinal chemistry vol. 53
Availability: No items available.
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40.
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Spiroindolones, a potent compound class for the treatment of malaria. [electronic resource] by
- Rottmann, Matthias
- McNamara, Case
- Yeung, Bryan K S
- Lee, Marcus C S
- Zou, Bin
- Russell, Bruce
- Seitz, Patrick
- Plouffe, David M
- Dharia, Neekesh V
- Tan, Jocelyn
- Cohen, Steven B
- Spencer, Kathryn R
- González-Páez, Gonzalo E
- Lakshminarayana, Suresh B
- Goh, Anne
- Suwanarusk, Rossarin
- Jegla, Timothy
- Schmitt, Esther K
- Beck, Hans-Peter
- Brun, Reto
- Nosten, Francois
- Renia, Laurent
- Dartois, Veronique
- Keller, Thomas H
- Fidock, David A
- Winzeler, Elizabeth A
- Diagana, Thierry T
Producer: 20100927
In:
Science (New York, N.Y.) vol. 329
Availability: No items available.
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