Results
|
21.
|
Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. [electronic resource] by
- Lobell, Robert B
- Liu, Dongming
- Buser, Carolyn A
- Davide, Joseph P
- DePuy, Elizabeth
- Hamilton, Kelly
- Koblan, Kenneth S
- Lee, Yih
- Mosser, Scott
- Motzel, Sherri L
- Abbruzzese, James L
- Fuchs, Charles S
- Rowinsky, Eric K
- Rubin, Eric H
- Sharma, Sunil
- Deutsch, Paul J
- Mazina, Kathryn E
- Morrison, Briggs W
- Wildonger, Lynne
- Yao, Siu-Long
- Kohl, Nancy E
Producer: 20030113
In:
Molecular cancer therapeutics vol. 1
Availability: No items available.
|
|
22.
|
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP. [electronic resource] by
- Coleman, Paul J
- Schreier, John D
- Cox, Christopher D
- Fraley, Mark E
- Garbaccio, Robert M
- Buser, Carolyn A
- Walsh, Eileen S
- Hamilton, Kelly
- Lobell, Robert B
- Rickert, Keith
- Tao, Weikang
- Diehl, Ronald E
- South, Vicki J
- Davide, Joseph P
- Kohl, Nancy E
- Yan, Youwei
- Kuo, Lawrence
- Prueksaritanont, Thomayant
- Li, Chunze
- Mahan, Elizabeth A
- Fernandez-Metzler, Carmen
- Salata, Joseph J
- Hartman, George D
Producer: 20071127
In:
Bioorganic & medicinal chemistry letters vol. 17
Availability: No items available.
|
|
23.
|
MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. [electronic resource] by
- Pan, Bo-Sheng
- Chan, Grace K Y
- Chenard, Melissa
- Chi, An
- Davis, Lenora J
- Deshmukh, Sujal V
- Gibbs, Jackson B
- Gil, Susana
- Hang, Gaozhen
- Hatch, Harold
- Jewell, James P
- Kariv, Ilona
- Katz, Jason D
- Kunii, Kaiko
- Lu, Wei
- Lutterbach, Bart A
- Paweletz, Cloud P
- Qu, Xianlu
- Reilly, John F
- Szewczak, Alexander A
- Zeng, Qinwen
- Kohl, Nancy E
- Dinsmore, Christopher J
Producer: 20100407
In:
Cancer research vol. 70
Availability: No items available.
|
|
24.
|
Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP. [electronic resource] by
- Fraley, Mark E
- Garbaccio, Robert M
- Arrington, Kenneth L
- Hoffman, William F
- Tasber, Edward S
- Coleman, Paul J
- Buser, Carolyn A
- Walsh, Eileen S
- Hamilton, Kelly
- Fernandes, Christine
- Schaber, Michael D
- Lobell, Robert B
- Tao, Weikang
- South, Victoria J
- Yan, Youwei
- Kuo, Lawrence C
- Prueksaritanont, Thomayant
- Shu, Cathy
- Torrent, Maricel
- Heimbrook, David C
- Kohl, Nancy E
- Huber, Hans E
- Hartman, George D
Producer: 20060719
In:
Bioorganic & medicinal chemistry letters vol. 16
Availability: No items available.
|
|
25.
|
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility. [electronic resource] by
- Garbaccio, Robert M
- Fraley, Mark E
- Tasber, Edward S
- Olson, Christy M
- Hoffman, William F
- Arrington, Kenneth L
- Torrent, Maricel
- Buser, Carolyn A
- Walsh, Eileen S
- Hamilton, Kelly
- Schaber, Michael D
- Fernandes, Christine
- Lobell, Robert B
- Tao, Weikang
- South, Vicki J
- Yan, Youwei
- Kuo, Lawrence C
- Prueksaritanont, Thomayant
- Slaughter, Donald E
- Shu, Cathy
- Heimbrook, David C
- Kohl, Nancy E
- Huber, Hans E
- Hartman, George D
Producer: 20060719
In:
Bioorganic & medicinal chemistry letters vol. 16
Availability: No items available.
|
|
26.
|
Mediator kinase inhibition further activates super-enhancer-associated genes in AML. [electronic resource] by
- Pelish, Henry E
- Liau, Brian B
- Nitulescu, Ioana I
- Tangpeerachaikul, Anupong
- Poss, Zachary C
- Da Silva, Diogo H
- Caruso, Brittany T
- Arefolov, Alexander
- Fadeyi, Olugbeminiyi
- Christie, Amanda L
- Du, Karrie
- Banka, Deepti
- Schneider, Elisabeth V
- Jestel, Anja
- Zou, Ge
- Si, Chong
- Ebmeier, Christopher C
- Bronson, Roderick T
- Krivtsov, Andrei V
- Myers, Andrew G
- Kohl, Nancy E
- Kung, Andrew L
- Armstrong, Scott A
- Lemieux, Madeleine E
- Taatjes, Dylan J
- Shair, Matthew D
Producer: 20160330
In:
Nature vol. 526
Availability: No items available.
|
|
27.
|
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP. [electronic resource] by
- Garbaccio, Robert M
- Tasber, Edward S
- Neilson, Lou Anne
- Coleman, Paul J
- Fraley, Mark E
- Olson, Christy
- Bergman, Jeff
- Torrent, Maricel
- Buser, Carolyn A
- Rickert, Keith
- Walsh, Eileen S
- Hamilton, Kelly
- Lobell, Robert B
- Tao, Weikang
- South, Vicki J
- Diehl, Ronald E
- Davide, Joseph P
- Yan, Youwei
- Kuo, Lawrence C
- Li, Chunze
- Prueksaritanont, Thomayant
- Fernandez-Metzler, Carmen
- Mahan, Elizabeth A
- Slaughter, Donald E
- Salata, Joseph J
- Kohl, Nancy E
- Huber, Hans E
- Hartman, George D
Producer: 20071212
In:
Bioorganic & medicinal chemistry letters vol. 17
Availability: No items available.
|
|
28.
|
Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. [electronic resource] by
- Cox, Christopher D
- Coleman, Paul J
- Breslin, Michael J
- Whitman, David B
- Garbaccio, Robert M
- Fraley, Mark E
- Buser, Carolyn A
- Walsh, Eileen S
- Hamilton, Kelly
- Schaber, Michael D
- Lobell, Robert B
- Tao, Weikang
- Davide, Joseph P
- Diehl, Ronald E
- Abrams, Marc T
- South, Vicki J
- Huber, Hans E
- Torrent, Maricel
- Prueksaritanont, Thomayant
- Li, Chunze
- Slaughter, Donald E
- Mahan, Elizabeth
- Fernandez-Metzler, Carmen
- Yan, Youwei
- Kuo, Lawrence C
- Kohl, Nancy E
- Hartman, George D
Producer: 20080829
In:
Journal of medicinal chemistry vol. 51
Availability: No items available.
|
|
29.
|
3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. [electronic resource] by
- Bell, Ian M
- Gallicchio, Steven N
- Abrams, Marc
- Beese, Lorena S
- Beshore, Douglas C
- Bhimnathwala, Hema
- Bogusky, Michael J
- Buser, Carolyn A
- Culberson, J Christopher
- Davide, Joseph
- Ellis-Hutchings, Michelle
- Fernandes, Christine
- Gibbs, Jackson B
- Graham, Samuel L
- Hamilton, Kelly A
- Hartman, George D
- Heimbrook, David C
- Homnick, Carl F
- Huber, Hans E
- Huff, Joel R
- Kassahun, Kelem
- Koblan, Kenneth S
- Kohl, Nancy E
- Lobell, Robert B
- Lynch, Joseph J
- Robinson, Ronald
- Rodrigues, A David
- Taylor, Jeffrey S
- Walsh, Eileen S
- Williams, Theresa M
- Zartman, C Blair
Producer: 20020627
In:
Journal of medicinal chemistry vol. 45
Availability: No items available.
|
|
30.
|
First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma. [electronic resource] by
- Kim, Richard D
- Sarker, Debashis
- Meyer, Tim
- Yau, Thomas
- Macarulla, Teresa
- Park, Joong-Won
- Choo, Su Pin
- Hollebecque, Antoine
- Sung, Max W
- Lim, Ho-Yeong
- Mazzaferro, Vincenzo
- Trojan, Joerg
- Zhu, Andrew X
- Yoon, Jung-Hwan
- Sharma, Sunil
- Lin, Zhong-Zhe
- Chan, Stephen L
- Faivre, Sandrine
- Feun, Lynn G
- Yen, Chia-Jui
- Dufour, Jean-Francois
- Palmer, Daniel H
- Llovet, Josep M
- Manoogian, Melissa
- Tugnait, Meera
- Stransky, Nicolas
- Hagel, Margit
- Kohl, Nancy E
- Lengauer, Christoph
- Sherwin, Cori Ann
- Schmidt-Kittler, Oleg
- Hoeflich, Klaus P
- Shi, Hongliang
- Wolf, Beni B
- Kang, Yoon-Koo
Producer: 20200807
In:
Cancer discovery vol. 9
Availability: No items available.
|