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	21.	Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells. [electronic resource] by Parthasarathy, Varadarajan Martin, Francine Higginbottom, Adrian Murray, Helen Moseley, Gregory W Read, Robert C Mal, Gorakh Hulme, Rachel Monk, Peter N Partridge, Lynda J Producer: 20090731 In: Immunology vol. 127 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	22.	Oligogenic inheritance of optineurin (OPTN) and C9ORF72 mutations in ALS highlights localisation of OPTN in the TDP-43-negative inclusions of C9ORF72-ALS. [electronic resource] by Bury, Joanna J Highley, J Robin Cooper-Knock, Johnathan Goodall, Emily F Higginbottom, Adrian McDermott, Christopher J Ince, Paul G Shaw, Pamela J Kirby, Janine Producer: 20170109 In: Neuropathology : official journal of the Japanese Society of Neuropathology vol. 36 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	23.	Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. [electronic resource] by Higginbottom, Adrian Cain, Stuart A Woodruff, Trent M Proctor, Lavinia M Madala, Praveen K Tyndall, Joel D A Taylor, Stephen M Fairlie, David P Monk, Peter N Producer: 20050902 In: The Journal of biological chemistry vol. 280 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	24.	C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis. [electronic resource] by Cooper-Knock, Johnathan Bury, Joanna J Heath, Paul R Wyles, Matthew Higginbottom, Adrian Gelsthorpe, Catherine Highley, J Robin Hautbergue, Guillaume Rattray, Magnus Kirby, Janine Shaw, Pamela J Producer: 20160404 In: PloS one vol. 10 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	25.	Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy. [electronic resource] by Cooper-Knock, Johnathan Higginbottom, Adrian Stopford, Matthew J Highley, J Robin Ince, Paul G Wharton, Stephen B Pickering-Brown, Stuart Kirby, Janine Hautbergue, Guillaume M Shaw, Pamela J Producer: 20160322 In: Acta neuropathologica vol. 130 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	26.	Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. [electronic resource] by Wood-Allum, Clare A Barber, Siân C Kirby, Janine Heath, Paul Holden, Hazel Mead, Richard Higginbottom, Adrian Allen, Simon Beaujeux, Tim Alexson, Stefan E Ince, Paul G Shaw, Pamela J Producer: 20060803 In: Brain : a journal of neurology vol. 129 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	27.	Intermediate length C9orf72 expansion in an ALS patient without classical C9orf72 neuropathology. [electronic resource] by Beer, Alexander M Cooper-Knock, Johnathan Higginbottom, Adrian Highley, J Robin Wharton, Stephen B Ince, Paul G Milano, Antonio Jones, Ashley A Al-Chalabi, Ammar Kirby, Janine Shaw, Pamela J Producer: 20160212 In: Amyotrophic lateral sclerosis & frontotemporal degeneration vol. 16 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	28.	TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons. [electronic resource] by Vogt, Miriam A Ehsaei, Zahra Knuckles, Philip Higginbottom, Adrian Helmbrecht, Michaela S Kunath, Tilo Eggan, Kevin Williams, Luis A Shaw, Pamela J Wurst, Wolfgang Floss, Thomas Huber, Andrea B Taylor, Verdon Producer: 20191007 In: Scientific reports vol. 8 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	29.	Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype. [electronic resource] by Cooper-Knock, Johnathan Robins, Henry Niedermoser, Isabell Wyles, Matthew Heath, Paul R Higginbottom, Adrian Walsh, Theresa Kazoka, Mbombe Ince, Paul G Hautbergue, Guillaume M McDermott, Christopher J Kirby, Janine Shaw, Pamela J Publication details: Frontiers in molecular neuroscience 2017 In: Frontiers in molecular neuroscience vol. 10 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	30.	S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis. [electronic resource] by Mead, Richard J Higginbottom, Adrian Allen, Scott P Kirby, Janine Bennett, Ellen Barber, Siân C Heath, Paul R Coluccia, Antonio Patel, Neelam Gardner, Iain Brancale, Andrea Grierson, Andrew J Shaw, Pamela J Producer: 20150821 In: Free radical biology & medicine vol. 61 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	31.	Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions. [electronic resource] by Cooper-Knock, Johnathan Walsh, Matthew J Higginbottom, Adrian Robin Highley, J Dickman, Mark J Edbauer, Dieter Ince, Paul G Wharton, Stephen B Wilson, Stuart A Kirby, Janine Hautbergue, Guillaume M Shaw, Pamela J Producer: 20140825 In: Brain : a journal of neurology vol. 137 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	32.	Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones. [electronic resource] by Highley, J Robin Kirby, Janine Jansweijer, Joeri A Webb, Philip S Hewamadduma, Channa A Heath, Paul R Higginbottom, Adrian Raman, Rohini Ferraiuolo, Laura Cooper-Knock, Johnathan McDermott, Christopher J Wharton, Stephen B Shaw, Pamela J Ince, Paul G Producer: 20150527 In: Neuropathology and applied neurobiology vol. 40 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	33.	Viral delivery of [electronic resource] by Herranz-Martin, Saul Chandran, Jayanth Lewis, Katherine Mulcahy, Padraig Higginbottom, Adrian Walker, Callum Valenzuela, Isabel Martinez-Pena Y Jones, Ross A Coldicott, Ian Iannitti, Tommaso Akaaboune, Mohammed El-Khamisy, Sherif F Gillingwater, Thomas H Shaw, Pamela J Azzouz, Mimoun Producer: 20180330 In: Disease models & mechanisms vol. 10 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	34.	Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS. [electronic resource] by Iannitti, Tommaso Scarrott, Joseph M Likhite, Shibi Coldicott, Ian R P Lewis, Katherine E Heath, Paul R Higginbottom, Adrian Myszczynska, Monika A Milo, Marta Hautbergue, Guillaume M Meyer, Kathrin Kaspar, Brian K Ferraiuolo, Laura Shaw, Pamela J Azzouz, Mimoun Publication details: Molecular therapy. Nucleic acids Sep 2018 In: Molecular therapy. Nucleic acids vol. 12 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	35.	C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten. [electronic resource] by Stopford, Matthew J Higginbottom, Adrian Hautbergue, Guillaume M Cooper-Knock, Johnathan Mulcahy, Padraig J De Vos, Kurt J Renton, Alan E Pliner, Hannah Calvo, Andrea Chio, Adriano Traynor, Bryan J Azzouz, Mimoun Heath, Paul R Kirby, Janine Shaw, Pamela J Producer: 20170515 In: Human molecular genetics vol. 26 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	36.	The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. [electronic resource] by Webster, Christopher P Smith, Emma F Bauer, Claudia S Moller, Annekathrin Hautbergue, Guillaume M Ferraiuolo, Laura Myszczynska, Monika A Higginbottom, Adrian Walsh, Matthew J Whitworth, Alexander J Kaspar, Brian K Meyer, Kathrin Shaw, Pamela J Grierson, Andrew J De Vos, Kurt J Producer: 20170626 In: The EMBO journal vol. 35 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	37.	Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS). [electronic resource] by Cox, Laura E Ferraiuolo, Laura Goodall, Emily F Heath, Paul R Higginbottom, Adrian Mortiboys, Heather Hollinger, Hannah C Hartley, Judith A Brockington, Alice Burness, Christine E Morrison, Karen E Wharton, Stephen B Grierson, Andrew J Ince, Paul G Kirby, Janine Shaw, Pamela J Producer: 20110111 In: PloS one vol. 5 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	38.	C9orf72 expansion disrupts ATM-mediated chromosomal break repair. [electronic resource] by Walker, Callum Herranz-Martin, Saul Karyka, Evangelia Liao, Chunyan Lewis, Katherine Elsayed, Waheba Lukashchuk, Vera Chiang, Shih-Chieh Ray, Swagat Mulcahy, Padraig J Jurga, Mateusz Tsagakis, Ioannis Iannitti, Tommaso Chandran, Jayanth Coldicott, Ian De Vos, Kurt J Hassan, Mohamed K Higginbottom, Adrian Shaw, Pamela J Hautbergue, Guillaume M Azzouz, Mimoun El-Khamisy, Sherif F Producer: 20170915 In: Nature neuroscience vol. 20 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	39.	Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis. [electronic resource] by Allen, Scott P Hall, Benjamin Castelli, Lydia M Francis, Laura Woof, Ryan Siskos, Alexandros P Kouloura, Eirini Gray, Elizabeth Thompson, Alexander G Talbot, Kevin Higginbottom, Adrian Myszczynska, Monika Allen, Chloe F Stopford, Matthew J Hemingway, Jordan Bauer, Claudia S Webster, Christopher P De Vos, Kurt J Turner, Martin R Keun, Hector C Hautbergue, Guillaume M Ferraiuolo, Laura Shaw, Pamela J Producer: 20200106 In: Brain : a journal of neurology vol. 142 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	40.	Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis. [electronic resource] by Cooper-Knock, Johnathan Moll, Tobias Ramesh, Tennore Castelli, Lydia Beer, Alexander Robins, Henry Fox, Ian Niedermoser, Isabell Van Damme, Philip Moisse, Matthieu Robberecht, Wim Hardiman, Orla Panades, Monica P Assialioui, Abdelilah Mora, Jesus S Basak, A Nazli Morrison, Karen E Shaw, Christopher E Al-Chalabi, Ammar Landers, John E Wyles, Matthew Heath, Paul R Higginbottom, Adrian Walsh, Theresa Kazoka, Mbombe McDermott, Christopher J Hautbergue, Guillaume M Kirby, Janine Shaw, Pamela J Producer: 20200416 In: Cell reports vol. 26 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)

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