Results
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21.
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(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a novel ATP-sensitive potassium channel opener: hemodynamic comparison to ZD-6169, WAY-133537, and nifedipine in the anesthetized canine. [electronic resource] by
- Fryer, Ryan M
- Preusser, Lee C
- Calzadilla, Samuel V
- Hu, Yanhui
- Xu, Hongyu
- Marsh, Kennan C
- Cox, Bryan F
- Lin, C Thomas
- Gopalakrishnan, Murali
- Reinhart, Glenn A
Producer: 20050428
In:
Journal of cardiovascular pharmacology vol. 44
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22.
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23.
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Strategic integration of in vivo cardiovascular models during lead optimization: predictive value of 4 models independent of species, route of administration, and influence of anesthesia. [electronic resource] by
- Fryer, Ryan M
- Harrison, Paul C
- Muthukumarana, Akalushi
- Nodop Mazurek, Suzanne G
- Ng, Khing Jow
- Chen, Rong Rhonda
- Harrington, Kyle E
- Dinallo, Roger M
- Chi, Liguo
- Reinhart, Glenn A
Producer: 20120810
In:
Journal of cardiovascular pharmacology vol. 59
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24.
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Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet. [electronic resource] by
- Fryer, Ryan M
- Segreti, Jason A
- Widomski, Deborah L
- Franklin, Pamela H
- Banfor, Patricia N
- Koch, Kristin A
- Nakane, Masaki
- Wu-Wong, J Ruth
- Cox, Bryan F
- Reinhart, Glenn A
Producer: 20071105
In:
The Journal of pharmacology and experimental therapeutics vol. 323
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25.
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The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat. [electronic resource] by
- Fryer, Ryan M
- Muthukumarana, Akalushi
- Harrison, Paul C
- Nodop Mazurek, Suzanne
- Chen, Rong Rhonda
- Harrington, Kyle E
- Dinallo, Roger M
- Horan, Joshua C
- Patnaude, Lori
- Modis, Louise K
- Reinhart, Glenn A
Producer: 20130723
In:
PloS one vol. 7
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26.
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Pharmacological characterization of the novel dihydropyridine potassium channel opener, (9R)-9-(3-iodo-4-methylphenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione (A-325100), and the regulation of cardiovascular function in conscious and anesthetized beagle dogs. [electronic resource] by
- Fryer, Ryan M
- Rakestraw, Pamela A
- Preusser, Lee C
- Brune, Michael E
- Carroll, William A
- Buckner, Steven A
- Shieh, Char-Chang
- King, Linda L
- Marsh, Kennan C
- Gopalakrishnan, Murali
- Cox, Bryan F
- Reinhart, Glenn A
Producer: 20051122
In:
Journal of cardiovascular pharmacology vol. 46
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27.
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Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice. [electronic resource] by
- Essop, M Faadiel
- Camp, Heidi S
- Choi, Cheol Soo
- Sharma, Saumya
- Fryer, Ryan M
- Reinhart, Glenn A
- Guthrie, Patrick H
- Bentebibel, Assia
- Gu, Zeiwei
- Shulman, Gerald I
- Taegtmeyer, Heinrich
- Wakil, Salih J
- Abu-Elheiga, Lutfi
Producer: 20080821
In:
American journal of physiology. Heart and circulatory physiology vol. 295
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28.
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12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses. [electronic resource] by
- Patel, Hemal H
- Fryer, Ryan M
- Gross, Eric R
- Bundey, Richard A
- Hsu, Anna K
- Isbell, Marilyn
- Eusebi, Leonard O V
- Jensen, Roderick V
- Gullans, Steven R
- Insel, Paul A
- Nithipatikom, Kasem
- Gross, Garrett J
Producer: 20030429
In:
Circulation research vol. 92
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29.
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Effect of the multitargeted receptor tyrosine kinase inhibitor, ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea], on blood pressure in conscious rats and mice: reversal with antihypertensive agents and effect on tumor growth inhibition. [electronic resource] by
- Franklin, Pamela H
- Banfor, Patricia N
- Tapang, Paul
- Segreti, Jason A
- Widomski, Deborah L
- Larson, Kelly J
- Noonan, William T
- Gintant, Gary A
- Davidsen, Steven K
- Albert, Daniel H
- Fryer, Ryan M
- Cox, Bryan F
Producer: 20090623
In:
The Journal of pharmacology and experimental therapeutics vol. 329
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30.
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A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat. [electronic resource] by
- Boustany-Kari, Carine M
- Harrison, Paul C
- Chen, Hongxing
- Lincoln, Kathleen A
- Qian, Hu Sheng
- Clifford, Holly
- Wang, Hong
- Zhang, Xiaomei
- Gueneva-Boucheva, Kristina
- Bosanac, Todd
- Wong, Diane
- Fryer, Ryan M
- Richman, Jeremy G
- Sarko, Chris
- Pullen, Steven S
Producer: 20160622
In:
The Journal of pharmacology and experimental therapeutics vol. 356
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31.
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G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism. [electronic resource] by
- Fryer, Ryan M
- Ng, Khing Jow
- Nodop Mazurek, Suzanne G
- Patnaude, Lori
- Skow, Donna J
- Muthukumarana, Akalushi
- Gilpin, Kyle E
- Dinallo, Roger M
- Kuzmich, Daniel
- Lord, John
- Sanyal, Sulagna
- Yu, Hui
- Harcken, Christian
- Cerny, Matthew A
- Cerny, Matthew C
- Hickey, Eugene R
- Modis, Louise K
Producer: 20140402
In:
The Journal of pharmacology and experimental therapeutics vol. 348
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32.
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CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells. [electronic resource] by
- Lewis, Nuruddeen D
- Muthukumarana, Akalushi
- Fogal, Steven E
- Corradini, Laura
- Stefanopoulos, Dimitria E
- Adusumalli, Prathima
- Pelletier, Josephine
- Panzenbeck, Mark
- Berg, Karen
- Canfield, Melissa
- Cook, Brian N
- Razavi, Hossein
- Kuzmich, Daniel
- Anderson, Shawn
- Allard, Devan
- Harrison, Paul
- Grimaldi, Christine
- Souza, Donald
- Harcken, Christian
- Fryer, Ryan M
- Modis, Louise K
- Brown, Maryanne L
Producer: 20150626
In:
PloS one vol. 9
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33.
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Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists. [electronic resource] by
- Altenbach, Robert J
- Liu, Huaqing
- Banfor, Patricia N
- Browman, Kaitlin E
- Fox, Gerard B
- Fryer, Ryan M
- Komater, Victoria A
- Krueger, Kathleen M
- Marsh, Kennan
- Miller, Thomas R
- Pan, Jia Bao
- Pan, Liping
- Sun, Minghua
- Thiffault, Christine
- Wetter, Jill
- Zhao, Chen
- Zhou, Deliang
- Esbenshade, Timothy A
- Hancock, Arthur A
- Cowart, Marlon D
Producer: 20071206
In:
Journal of medicinal chemistry vol. 50
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34.
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Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitors. [electronic resource] by
- Fryer, Ryan M
- Muthukumarana, Akalushi
- Chen, Rong Rhonda
- Smith, James D
- Mazurek, Suzanne Nodop
- Harrington, Kyle E
- Dinallo, Roger M
- Burke, Jennifer
- DiCapua, Frank M
- Guo, Xin
- Kirrane, Thomas M
- Snow, Roger J
- Zhang, Yunlong
- Soleymanzadeh, Fariba
- Madwed, Jeffrey B
- Kashem, Mohammed A
- Kugler, Stanley Z
- O'Neill, Margaret M
- Harrison, Paul C
- Reinhart, Glenn A
- Boyer, Stephen J
Producer: 20120504
In:
The Journal of pharmacology and experimental therapeutics vol. 340
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35.
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Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. [electronic resource] by
- Pei, Zhonghua
- Li, Xiaofeng
- von Geldern, Thomas W
- Madar, David J
- Longenecker, Kenton
- Yong, Hong
- Lubben, Thomas H
- Stewart, Kent D
- Zinker, Bradley A
- Backes, Bradley J
- Judd, Andrew S
- Mulhern, Mathew
- Ballaron, Stephen J
- Stashko, Michael A
- Mika, Amanda K
- Beno, David W A
- Reinhart, Glenn A
- Fryer, Ryan M
- Preusser, Lee C
- Kempf-Grote, Anita J
- Sham, Hing L
- Trevillyan, James M
Producer: 20061205
In:
Journal of medicinal chemistry vol. 49
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36.
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Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists. [electronic resource] by
- Kym, Philip R
- Souers, Andrew J
- Campbell, Thomas J
- Lynch, John K
- Judd, Andrew S
- Iyengar, Rajesh
- Vasudevan, Anil
- Gao, Ju
- Freeman, Jennifer C
- Wodka, Dariusz
- Mulhern, Mathew
- Zhao, Gang
- Wagaw, Seble H
- Napier, James J
- Brodjian, Sevan
- Dayton, Brian D
- Reilly, Regina M
- Segreti, Jason A
- Fryer, Ryan M
- Preusser, Lee C
- Reinhart, Glenn A
- Hernandez, Lisa
- Marsh, Kennan C
- Sham, Hing L
- Collins, Christine A
- Polakowski, James S
Producer: 20060502
In:
Journal of medicinal chemistry vol. 49
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37.
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Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia. [electronic resource] by
- Honore, Prisca
- Chandran, Prasant
- Hernandez, Gricelda
- Gauvin, Donna M
- Mikusa, Joseph P
- Zhong, Chengmin
- Joshi, Shailen K
- Ghilardi, Joseph R
- Sevcik, Molly A
- Fryer, Ryan M
- Segreti, Jason A
- Banfor, Patricia N
- Marsh, Kennan
- Neelands, Torben
- Bayburt, Erol
- Daanen, Jerome F
- Gomtsyan, Arthur
- Lee, Chih-Hung
- Kort, Michael E
- Reilly, Regina M
- Surowy, Carol S
- Kym, Philip R
- Mantyh, Patrick W
- Sullivan, James P
- Jarvis, Michael F
- Faltynek, Connie R
Producer: 20090610
In:
Pain vol. 142
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38.
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Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety. [electronic resource] by
- Lynch, John K
- Freeman, Jennifer C
- Judd, Andrew S
- Iyengar, Rajesh
- Mulhern, Mathew
- Zhao, Gang
- Napier, James J
- Wodka, Dariusz
- Brodjian, Sevan
- Dayton, Brian D
- Falls, Doug
- Ogiela, Christopher
- Reilly, Regina M
- Campbell, Thomas J
- Polakowski, James S
- Hernandez, Lisa
- Marsh, Kennan C
- Shapiro, Robin
- Knourek-Segel, Victoria
- Droz, Brian
- Bush, Eugene
- Brune, Michael
- Preusser, Lee C
- Fryer, Ryan M
- Reinhart, Glenn A
- Houseman, Kathryn
- Diaz, Gilbert
- Mikhail, Ann
- Limberis, James T
- Sham, Hing L
- Collins, Christine A
- Kym, Philip R
Producer: 20061205
In:
Journal of medicinal chemistry vol. 49
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39.
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Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes. [electronic resource] by
- Madar, David J
- Kopecka, Hana
- Pireh, Daisy
- Yong, Hong
- Pei, Zhonghua
- Li, Xiaofeng
- Wiedeman, Paul E
- Djuric, Stevan W
- Von Geldern, Thomas W
- Fickes, Michael G
- Bhagavatula, Lakshmi
- McDermott, Todd
- Wittenberger, Steven
- Richards, Steven J
- Longenecker, Kenton L
- Stewart, Kent D
- Lubben, Thomas H
- Ballaron, Stephen J
- Stashko, Michael A
- Long, Michelle A
- Wells, Heidi
- Zinker, Bradley A
- Mika, Amanda K
- Beno, David W A
- Kempf-Grote, Anita J
- Polakowski, James
- Segreti, Jason
- Reinhart, Glenn A
- Fryer, Ryan M
- Sham, Hing L
- Trevillyan, James M
Producer: 20061204
In:
Journal of medicinal chemistry vol. 49
Availability: No items available.
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40.
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Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties. [electronic resource] by
- Tietje, Karin R
- Anderson, David J
- Bitner, R Scott
- Blomme, Eric A
- Brackemeyer, Paul J
- Briggs, Clark A
- Browman, Kaitlin E
- Bury, Dagmar
- Curzon, Peter
- Drescher, Karla U
- Frost, Jennifer M
- Fryer, Ryan M
- Fox, Gerard B
- Gronlien, Jens Halvard
- Håkerud, Monika
- Gubbins, Earl J
- Halm, Sabine
- Harris, Richard
- Helfrich, Rosalind J
- Kohlhaas, Kathy L
- Law, Devalina
- Malysz, John
- Marsh, Kennan C
- Martin, Ruth L
- Meyer, Michael D
- Molesky, Angela L
- Nikkel, Arthur L
- Otte, Stephani
- Pan, Liping
- Puttfarcken, Pamela S
- Radek, Richard J
- Robb, Holly M
- Spies, Eva
- Thorin-Hagene, Kirsten
- Waring, Jeffrey F
- Ween, Hilde
- Xu, Hongyu
- Gopalakrishnan, Murali
- Bunnelle, William H
Producer: 20080801
In:
CNS neuroscience & therapeutics vol. 14
Availability: No items available.
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