Results
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161.
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Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254). [electronic resource] by
- Turlington, Mark
- Noetzel, Meredith J
- Chun, Aspen
- Zhou, Ya
- Gogliotti, Rocco D
- Nguyen, Elizabeth D
- Gregory, Karen J
- Vinson, Paige N
- Rook, Jerri M
- Gogi, Kiran K
- Xiang, Zixiu
- Bridges, Thomas M
- Daniels, J Scott
- Jones, Carrie
- Niswender, Colleen M
- Meiler, Jens
- Conn, P Jeffrey
- Lindsley, Craig W
- Stauffer, Shaun R
Producer: 20140310
In:
Journal of medicinal chemistry vol. 56
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162.
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Challenges in the development of an M [electronic resource] by
- Tarr, James C
- Wood, Michael R
- Noetzel, Meredith J
- Bertron, Jeanette L
- Weiner, Rebecca L
- Rodriguez, Alice L
- Lamsal, Atin
- Byers, Frank W
- Chang, Sichen
- Cho, Hyekyung P
- Jones, Carrie K
- Niswender, Colleen M
- Wood, Michael W
- Brandon, Nicholas J
- Duggan, Mark E
- Conn, P Jeffrey
- Bridges, Thomas M
- Lindsley, Craig W
Producer: 20170818
In:
Bioorganic & medicinal chemistry letters vol. 27
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163.
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Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4). [electronic resource] by
- Engers, Darren W
- Blobaum, Anna L
- Gogliotti, Rocco D
- Cheung, Yiu-Yin
- Salovich, James M
- Garcia-Barrantes, Pedro M
- Daniels, J Scott
- Morrison, Ryan
- Jones, Carrie K
- Soars, Matthew G
- Zhuo, Xiaoliang
- Hurley, Jeremy
- Macor, John E
- Bronson, Joanne J
- Conn, P Jeffrey
- Lindsley, Craig W
- Niswender, Colleen M
- Hopkins, Corey R
Producer: 20171027
In:
ACS chemical neuroscience vol. 7
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164.
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Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. [electronic resource] by
- Rook, Jerri M
- Noetzel, Meredith J
- Pouliot, Wendy A
- Bridges, Thomas M
- Vinson, Paige N
- Cho, Hyekyung P
- Zhou, Ya
- Gogliotti, Rocco D
- Manka, Jason T
- Gregory, Karen J
- Stauffer, Shaun R
- Dudek, F Edward
- Xiang, Zixiu
- Niswender, Colleen M
- Daniels, J Scott
- Jones, Carrie K
- Lindsley, Craig W
- Conn, P Jeffrey
Producer: 20140428
In:
Biological psychiatry vol. 73
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165.
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Diverse Effects on M [electronic resource] by
- Rook, Jerri M
- Abe, Masahito
- Cho, Hyekyung P
- Nance, Kellie D
- Luscombe, Vincent B
- Adams, Jeffrey J
- Dickerson, Jonathan W
- Remke, Daniel H
- Garcia-Barrantes, Pedro M
- Engers, Darren W
- Engers, Julie L
- Chang, Sichen
- Foster, Jarrett J
- Blobaum, Anna L
- Niswender, Colleen M
- Jones, Carrie K
- Conn, P Jeffrey
- Lindsley, Craig W
Producer: 20170502
In:
ACS chemical neuroscience vol. 8
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166.
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Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover. [electronic resource] by
- Manka, Jason T
- Vinson, Paige N
- Gregory, Karen J
- Zhou, Ya
- Williams, Richard
- Gogi, Kiran
- Days, Emily
- Jadhav, Satya
- Herman, Elizabeth J
- Lavreysen, Hilde
- Mackie, Claire
- Bartolomé, José M
- Macdonald, Gregor J
- Steckler, Thomas
- Daniels, J Scott
- Weaver, C David
- Niswender, Colleen M
- Jones, Carrie K
- Conn, P Jeffrey
- Lindsley, Craig W
- Stauffer, Shaun R
Producer: 20130227
In:
Bioorganic & medicinal chemistry letters vol. 22
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167.
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Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound. [electronic resource] by
- Mueller, Ralf
- Dawson, Eric S
- Meiler, Jens
- Rodriguez, Alice L
- Chauder, Brian A
- Bates, Brittney S
- Felts, Andrew S
- Lamb, Jeffrey P
- Menon, Usha N
- Jadhav, Sataywan B
- Kane, Alexander S
- Jones, Carrie K
- Gregory, Karen J
- Niswender, Colleen M
- Conn, P Jeffrey
- Olsen, Christopher M
- Winder, Danny G
- Emmitte, Kyle A
- Lindsley, Craig W
Producer: 20120713
In:
ChemMedChem vol. 7
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168.
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Challenges in the development of an M [electronic resource] by
- Tarr, James C
- Wood, Michael R
- Noetzel, Meredith J
- Melancon, Bruce J
- Lamsal, Atin
- Luscombe, Vincent B
- Rodriguez, Alice L
- Byers, Frank W
- Chang, Sichen
- Cho, Hyekyung P
- Engers, Darren W
- Jones, Carrie K
- Niswender, Colleen M
- Wood, Michael W
- Brandon, Nicholas J
- Duggan, Mark E
- Conn, P Jeffrey
- Bridges, Thomas M
- Lindsley, Craig W
Producer: 20171218
In:
Bioorganic & medicinal chemistry letters vol. 27
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169.
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Corrigendum to "Challenges in the development of an M [electronic resource] by
- Tarr, James C
- Wood, Michael R
- Noetzel, Meredith J
- Melancon, Bruce J
- Lamsal, Atin
- Luscombe, Vincent B
- Rodriguez, Alice L
- Byers, Frank W
- Chang, Sichen
- Cho, Hyekyung P
- Engers, Darren W
- Jones, Carrie K
- Niswender, Colleen M
- Wood, Michael W
- Brandon, Nicholas J
- Duggan, Mark E
- Jeffrey Conn, P
- Bridges, Thomas M
- Lindsley, Craig W
Publication details: Bioorganic & medicinal chemistry letters 09 2018
In:
Bioorganic & medicinal chemistry letters vol. 28
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170.
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Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). [electronic resource] by
- Martín-Martín, María Luz
- Bartolomé-Nebreda, José Manuel
- Conde-Ceide, Susana
- Alonso de Diego, Sergio A
- López, Silvia
- Martínez-Viturro, Carlos M
- Tong, Han Min
- Lavreysen, Hilde
- Macdonald, Gregor J
- Steckler, Thomas
- Mackie, Claire
- Bridges, Thomas M
- Daniels, J Scott
- Niswender, Colleen M
- Noetzel, Meredith J
- Jones, Carrie K
- Conn, P Jeffrey
- Lindsley, Craig W
- Stauffer, Shaun R
Producer: 20151228
In:
Bioorganic & medicinal chemistry letters vol. 25
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171.
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Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation. [electronic resource] by
- Felts, Andrew S
- Rodriguez, Alice L
- Blobaum, Anna L
- Morrison, Ryan D
- Bates, Brittney S
- Thompson Gray, Analisa
- Rook, Jerri M
- Tantawy, Mohammed N
- Byers, Frank W
- Chang, Sichen
- Venable, Daryl F
- Luscombe, Vincent B
- Tamagnan, Gilles D
- Niswender, Colleen M
- Daniels, J Scott
- Jones, Carrie K
- Conn, P Jeffrey
- Lindsley, Craig W
- Emmitte, Kyle A
Producer: 20170811
In:
Journal of medicinal chemistry vol. 60
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172.
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Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects. [electronic resource] by
- Gould, Robert W
- Amato, Russell J
- Bubser, Michael
- Joffe, Max E
- Nedelcovych, Michael T
- Thompson, Analisa D
- Nickols, Hilary H
- Yuh, Johannes P
- Zhan, Xiaoyan
- Felts, Andrew S
- Rodriguez, Alice L
- Morrison, Ryan D
- Byers, Frank W
- Rook, Jerri M
- Daniels, John S
- Niswender, Colleen M
- Conn, P Jeffrey
- Emmitte, Kyle A
- Lindsley, Craig W
- Jones, Carrie K
Producer: 20161108
In:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. 41
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173.
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Discovery of VU2957 (Valiglurax): An mGlu [electronic resource] by
- Panarese, Joseph D
- Engers, Darren W
- Wu, Yong-Jin
- Bronson, Joanne J
- Macor, John E
- Chun, Aspen
- Rodriguez, Alice L
- Felts, Andrew S
- Engers, Julie L
- Loch, Matthew T
- Emmitte, Kyle A
- Castelhano, Arlindo L
- Kates, Michael J
- Nader, Michael A
- Jones, Carrie K
- Blobaum, Anna L
- Conn, P Jeffrey
- Niswender, Colleen M
- Hopkins, Corey R
- Lindsley, Craig W
Publication details: ACS medicinal chemistry letters Mar 2019
In:
ACS medicinal chemistry letters vol. 10
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174.
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Challenges in the development of an M [electronic resource] by
- Wood, Michael R
- Noetzel, Meredith J
- Poslusney, Michael S
- Melancon, Bruce J
- Tarr, James C
- Lamsal, Atin
- Chang, Sichen
- Luscombe, Vincent B
- Weiner, Rebecca L
- Cho, Hyekyung P
- Bubser, Michael
- Jones, Carrie K
- Niswender, Colleen M
- Wood, Michael W
- Engers, Darren W
- Brandon, Nicholas J
- Duggan, Mark E
- Conn, P Jeffrey
- Bridges, Thomas M
- Lindsley, Craig W
Producer: 20171002
In:
Bioorganic & medicinal chemistry letters vol. 27
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175.
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Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. [electronic resource] by
- Pulley, Jill M
- Shirey-Rice, Jana K
- Lavieri, Robert R
- Jerome, Rebecca N
- Zaleski, Nicole M
- Aronoff, David M
- Bastarache, Lisa
- Niu, Xinnan
- Holroyd, Kenneth J
- Roden, Dan M
- Skaar, Eric P
- Niswender, Colleen M
- Marnett, Lawrence J
- Lindsley, Craig W
- Ekstrom, Leeland B
- Bentley, Alan R
- Bernard, Gordon R
- Hong, Charles C
- Denny, Joshua C
Producer: 20171019
In:
Assay and drug development technologies vol. 15
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176.
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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. [electronic resource] by
- Rodriguez, Alice L
- Grier, Mark D
- Jones, Carrie K
- Herman, Elizabeth J
- Kane, Alexander S
- Smith, Randy L
- Williams, Richard
- Zhou, Ya
- Marlo, Joy E
- Days, Emily L
- Blatt, Tasha N
- Jadhav, Satyawan
- Menon, Usha N
- Vinson, Paige N
- Rook, Jerri M
- Stauffer, Shaun R
- Niswender, Colleen M
- Lindsley, Craig W
- Weaver, C David
- Conn, P Jeffrey
Producer: 20101217
In:
Molecular pharmacology vol. 78
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177.
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Optimization of M [electronic resource] by
- Melancon, Bruce J
- Wood, Michael R
- Noetzel, Meredith J
- Nance, Kellie D
- Engelberg, Eileen M
- Han, Changho
- Lamsal, Atin
- Chang, Sichen
- Cho, Hyekyung P
- Byers, Frank W
- Bubser, Michael
- Jones, Carrie K
- Niswender, Colleen M
- Wood, Michael W
- Engers, Darren W
- Wu, Dedong
- Brandon, Nicholas J
- Duggan, Mark E
- Conn, P Jeffrey
- Bridges, Thomas M
- Lindsley, Craig W
Producer: 20170919
In:
Bioorganic & medicinal chemistry letters vol. 27
Availability: No items available.
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178.
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Discovery and Optimization of Potent and CNS Penetrant M [electronic resource] by
- Bender, Aaron M
- Cho, Hyekyung P
- Nance, Kellie D
- Lingenfelter, Kaelyn S
- Luscombe, Vincent B
- Gentry, Patrick R
- Voigtritter, Karl
- Berizzi, Alice E
- Sexton, Patrick M
- Langmead, Christopher J
- Christopoulos, Arthur
- Locuson, Charles W
- Bridges, Thomas M
- Chang, Sichen
- O'Neill, Jordan C
- Zhan, Xiaoyan
- Niswender, Colleen M
- Jones, Carrie K
- Conn, P Jeffrey
- Lindsley, Craig W
Producer: 20190930
In:
ACS chemical neuroscience vol. 9
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179.
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Discovery of VU0467485/AZ13713945: An M [electronic resource] by
- Wood, Michael R
- Noetzel, Meredith J
- Melancon, Bruce J
- Poslusney, Michael S
- Nance, Kellie D
- Hurtado, Miguel A
- Luscombe, Vincent B
- Weiner, Rebecca L
- Rodriguez, Alice L
- Lamsal, Atin
- Chang, Sichen
- Bubser, Michael
- Blobaum, Anna L
- Engers, Darren W
- Niswender, Colleen M
- Jones, Carrie K
- Brandon, Nicholas J
- Wood, Michael W
- Duggan, Mark E
- Conn, P Jeffrey
- Bridges, Thomas M
- Lindsley, Craig W
Publication details: ACS medicinal chemistry letters Feb 2017
In:
ACS medicinal chemistry letters vol. 8
Availability: No items available.
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180.
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Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia. [electronic resource] by
- Conde-Ceide, Susana
- Alcázar, Jesús
- Alonso de Diego, Sergio A
- López, Silvia
- Martín-Martín, María Luz
- Martínez-Viturro, Carlos M
- Pena, Miguel-Angel
- Tong, Han Min
- Lavreysen, Hilde
- Mackie, Claire
- Bridges, Thomas M
- Daniels, J Scott
- Niswender, Colleen M
- Jones, Carrie K
- Macdonald, Gregor J
- Steckler, Thomas
- Conn, P Jeffrey
- Stauffer, Shaun R
- Lindsley, Craig W
- Bartolomé-Nebreda, José Manuel
Producer: 20161011
In:
Bioorganic & medicinal chemistry letters vol. 26
Availability: No items available.
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