Results
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101.
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A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists. [electronic resource] by
- Tucci, Fabio C
- Zhu, Yun-Fei
- Guo, Zhiqiang
- Gross, Timothy D
- Connors, Patrick J
- Struthers, R Scott
- Reinhart, Greg J
- Wang, Xiaochuan
- Saunders, John
- Chen, Chen
Producer: 20030520
In:
Bioorganic & medicinal chemistry letters vol. 12
Availability: No items available.
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102.
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Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists. [electronic resource] by
- Rowbottom, Martin W
- Tucci, Fabio C
- Zhu, Yun-Fei
- Guo, Zhiqiang
- Gross, Timothy D
- Reinhart, Greg J
- Xie, Qui
- Struthers, R Scott
- Saunders, John
- Chen, Chen
Producer: 20041222
In:
Bioorganic & medicinal chemistry letters vol. 14
Availability: No items available.
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103.
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Design of potent dicyclic (4-10/5-8) gonadotropin releasing hormone (GnRH) antagonists. [electronic resource] by
- Rivier, J E
- Struthers, R S
- Porter, J
- Lahrichi, S L
- Jiang, G
- Cervini, L A
- Ibea, M
- Kirby, D A
- Koerber, S C
- Rivier, C L
Producer: 20000413
In:
Journal of medicinal chemistry vol. 43
Availability: No items available.
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104.
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Atropisomeric property of 1-(2,6-difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil. [electronic resource] by
- Tucci, Fabio C
- Hu, Tao
- Mesleh, Michael F
- Bokser, Allan
- Allsopp, Eric
- Gross, Timothy D
- Guo, Zhiqiang
- Zhu, Yun-Fei
- Struthers, R Scott
- Ling, Nicholas
- Chen, Chen
Producer: 20060131
In:
Chirality vol. 17
Availability: No items available.
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105.
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5-Aryluracils as potent GnRH antagonists-Characterization of atropisomers. [electronic resource] by
- Zhao, Liren
- Guo, Zhiqiang
- Chen, Yongsheng
- Hu, Tao
- Wu, Dongpei
- Zhu, Yun-Fei
- Rowbottom, Martin
- Gross, Timothy D
- Tucci, Fabio C
- Struthers, R Scott
- Xie, Qiu
- Chen, Chen
Producer: 20080709
In:
Bioorganic & medicinal chemistry letters vol. 18
Availability: No items available.
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106.
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A high-throughput chemotaxis assay for pharmacological characterization of chemokine receptors: Utilization of U937 monocytic cells. [electronic resource] by
- Ott, Thomas R
- Pahuja, Anil
- Lio, Francisco M
- Mistry, Monica S
- Gross, Molly
- Hudson, Sarah C
- Wade, Warren S
- Simpson, Pedro B
- Struthers, R Scott
- Alleva, David G
Producer: 20050721
In:
Journal of pharmacological and toxicological methods vol. 51
Availability: No items available.
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107.
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A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonists. [electronic resource] by
- Zhu, Yun-Fei
- Wilcoxen, Keith
- Saunders, John
- Guo, Zhiqiang
- Gao, Yinghong
- Connors, Patrick J
- Gross, Timothy D
- Tucci, Fabio C
- Struthers, R Scott
- Reinhart, Greg J
- Xie, Qiu
- Chen, Chen
Producer: 20020618
In:
Bioorganic & medicinal chemistry letters vol. 12
Availability: No items available.
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108.
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Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists. [electronic resource] by
- Zhu, Yun-Fei
- Guo, Zhiqiang
- Gross, Timothy D
- Gao, Yinghong
- Connors, Patrick J
- Struthers, R Scott
- Xie, Qiu
- Tucci, Fabio C
- Reinhart, Greg J
- Wu, Dongpei
- Saunders, John
- Chen, Chen
Producer: 20030527
In:
Journal of medicinal chemistry vol. 46
Availability: No items available.
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109.
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Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists. [electronic resource] by
- Guo, Zhiqiang
- Wu, Dongpei
- Zhu, Yun-Fei
- Tucci, Fabio C
- Regan, Collin F
- Rowbottom, Martin W
- Struthers, R Scott
- Xie, Qiu
- Reijmers, Shelby
- Sullivan, Susan K
- Sai, Yang
- Chen, Chen
Producer: 20051205
In:
Bioorganic & medicinal chemistry letters vol. 15
Availability: No items available.
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110.
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Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists. [electronic resource] by
- Zhu, Yun-Fei
- Gross, Timothy D
- Guo, Zhiqiang
- Connors, Patrick J
- Gao, Yinghong
- Tucci, Fabio C
- Struthers, R Scott
- Reinhart, Greg J
- Saunders, John
- Chen, Ta Kung
- Killam Bonneville, Anne L
- Chen, Chen
Producer: 20030623
In:
Journal of medicinal chemistry vol. 46
Availability: No items available.
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111.
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Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5. [electronic resource] by
- Rowbottom, Martin W
- Tucci, Fabio C
- Connors, Patrick J
- Gross, Timothy D
- Zhu, Yun-Fei
- Guo, Zhiqiang
- Moorjani, Manisha
- Acevedo, Oscar
- Carter, Lee
- Sullivan, Susan K
- Xie, Qiu
- Fisher, Andrew
- Struthers, R Scott
- Saunders, John
- Chen, Chen
Producer: 20050324
In:
Bioorganic & medicinal chemistry letters vol. 14
Availability: No items available.
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112.
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Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902. [electronic resource] by
- Struthers, R Scott
- Xie, Qui
- Sullivan, Susan K
- Reinhart, Greg J
- Kohout, Trudy A
- Zhu, Yun-Fei
- Chen, Chen
- Liu, Xin-Jun
- Ling, Nicholas
- Yang, Weidong
- Maki, Richard A
- Bonneville, Anne K
- Chen, Ta-Kung
- Bozigian, Haig P
Producer: 20070227
In:
Endocrinology vol. 148
Availability: No items available.
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113.
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Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity. [electronic resource] by
- Chen, Chen
- Chen, Yongsheng
- Pontillo, Joseph
- Guo, Zhiqiang
- Huang, Charles Q
- Wu, Dongpei
- Madan, Ajay
- Chen, Takung
- Wen, Jenny
- Xie, Qiu
- Tucci, Fabio C
- Rowbottom, Martin
- Zhu, Yun-Fei
- Wade, Warren
- Saunders, John
- Bozigian, Haig
- Struthers, R Scott
Producer: 20080709
In:
Bioorganic & medicinal chemistry letters vol. 18
Availability: No items available.
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114.
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Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. [electronic resource] by
- Guo, Zhiqiang
- Zhu, Yun-Fei
- Gross, Timothy D
- Tucci, Fabio C
- Gao, Yinghong
- Moorjani, Manisha
- Connors, Patrick J
- Rowbottom, Martin W
- Chen, Yongsheng
- Struthers, R Scott
- Xie, Qiu
- Saunders, John
- Reinhart, Greg
- Chen, Ta Kung
- Bonneville, Anne L Killam
- Chen, Chen
Producer: 20040413
In:
Journal of medicinal chemistry vol. 47
Availability: No items available.
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115.
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Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties. [electronic resource] by
- Regan, Colin F
- Guo, Zhiqiang
- Chen, Yongsheng
- Huang, Charles Q
- Chen, Mi
- Jiang, Wanlong
- Rueter, Jaimie K
- Coon, Timothy
- Chen, Chen
- Saunders, John
- Brown, Michael S
- Betz, Steve F
- Struthers, R Scott
- Yang, Chun
- Wen, Jenny
- Madan, Ajay
- Zhu, Yun-Fei
Producer: 20081124
In:
Bioorganic & medicinal chemistry letters vol. 18
Availability: No items available.
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116.
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Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. [electronic resource] by
- Chen, Chen
- Wu, Dongpei
- Guo, Zhiqiang
- Xie, Qiu
- Reinhart, Greg J
- Madan, Ajay
- Wen, Jenny
- Chen, Takung
- Huang, Charles Q
- Chen, Mi
- Chen, Yongsheng
- Tucci, Fabio C
- Rowbottom, Martin
- Pontillo, Joseph
- Zhu, Yun-Fei
- Wade, Warren
- Saunders, John
- Bozigian, Haig
- Struthers, R Scott
Producer: 20090403
In:
Journal of medicinal chemistry vol. 51
Availability: No items available.
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117.
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3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization. [electronic resource] by
- Tucci, Fabio C
- Zhu, Yun-Fei
- Struthers, R Scott
- Guo, Zhiqiang
- Gross, Timothy D
- Rowbottom, Martin W
- Acevedo, Oscar
- Gao, Yinghong
- Saunders, John
- Xie, Qiu
- Reinhart, Greg J
- Liu, Xin-Jun
- Ling, Nicholas
- Bonneville, Anne K L
- Chen, Takung
- Bozigian, Haig
- Chen, Chen
Producer: 20050405
In:
Journal of medicinal chemistry vol. 48
Availability: No items available.
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118.
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Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists. [electronic resource] by
- Chen, Mi
- Guo, Zhiqiang
- Lanier, Marion C
- Zhao, Liren
- Betz, Stephen F
- Huang, Charles Q
- Loweth, Colin J
- Ashweek, Neil J
- Liu, Xin-Jun
- Struthers, R Scott
- Bradbury, Margaret J
- Behan, James W
- Wen, Jenny
- O'Brien, Zhihong
- Saunders, John
- Zhu, Yun-Fei
Producer: 20070924
In:
Bioorganic & medicinal chemistry letters vol. 17
Availability: No items available.
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119.
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3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor. [electronic resource] by
- Tucci, Fabio C
- Zhu, Yun-Fei
- Guo, Zhiqiang
- Gross, Timothy D
- Connors, Patrick J
- Gao, Yinghong
- Rowbottom, Martin W
- Struthers, R Scott
- Reinhart, Greg J
- Xie, Qiu
- Chen, Ta Kung
- Bozigian, Haig
- Killam Bonneville, Anne L
- Fisher, Andrew
- Jin, Liping
- Saunders, John
- Chen, Chen
Producer: 20040802
In:
Journal of medicinal chemistry vol. 47
Availability: No items available.
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