Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. [electronic resource]
- Molecular and cellular biology Mar 1999
- 2416-24 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0270-7306
10.1128/MCB.19.3.2416 doi
Animals Caspase 1--metabolism Cell Line DNA-Binding Proteins--genetics Enzyme Induction Fibroblasts--cytology Humans Interferon-alpha--metabolism Interferon-gamma--metabolism Intracellular Signaling Peptides and Proteins Janus Kinase 1 Membrane Proteins Mice Mutagenesis Phenotype Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatase, Non-Receptor Type 6 Protein Tyrosine Phosphatases--genetics Protein-Tyrosine Kinases--metabolism Receptor, Interferon alpha-beta Receptors, Interferon--metabolism SH2 Domain-Containing Protein Tyrosine Phosphatases STAT1 Transcription Factor STAT2 Transcription Factor Signal Transduction Trans-Activators--genetics Interferon gamma Receptor