Human single-chain Fv immunoconjugates targeted to a melanoma-associated chondroitin sulfate proteoglycan mediate specific lysis of human melanoma cells by natural killer cells and complement. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Feb 1999
- 1627-32 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0027-8424
10.1073/pnas.96.4.1627 doi
Animals Base Sequence CHO Cells Cell Line Cells, Cultured Chondroitin Sulfate Proteoglycans--immunology Chromatography, Liquid Complement System Proteins--immunology Cricetinae Cytotoxicity, Immunologic Drosophila melanogaster Endothelium, Vascular--immunology Humans Immunoconjugates--isolation & purification Immunoglobulin Fragments--genetics Immunoglobulin G--genetics Immunoglobulin Variable Region--genetics Killer Cells, Natural--immunology Mass Spectrometry Melanoma--immunology Molecular Sequence Data Restriction Mapping Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Transfection Tumor Cells, Cultured