Manna, S K <br/><br/>
Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression.  [electronic resource] 

 -  Journal of immunology (Baltimore, Md. : 1950)  Feb 1999 
 - 2095-102 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0022-1767 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aniline Compounds--antagonists & inhibitors<br/>Biological Transport--drug effects<br/>Cell Nucleus--drug effects<br/>Ceramides--antagonists & inhibitors<br/>Chloramphenicol O-Acetyltransferase--antagonists & inhibitors<br/>Crotonates<br/>DNA-Binding Proteins--antagonists & inhibitors<br/>Dithiothreitol--pharmacology<br/>Enzyme Activation--drug effects<br/>Gene Expression Regulation--drug effects<br/>Genes, MDR--drug effects<br/>Genes, Reporter--drug effects<br/>Host Cell Factor C1<br/>Humans<br/>Hydrogen Peroxide--antagonists & inhibitors<br/>Hydroxybutyrates--antagonists & inhibitors<br/>I-kappa B Proteins<br/>Immunosuppressive Agents--antagonists & inhibitors<br/>Isoxazoles--antagonists & inhibitors<br/>Leflunomide<br/>Lipopolysaccharides--antagonists & inhibitors<br/>Lymphocyte Specific Protein Tyrosine Kinase p56(lck)--antagonists & inhibitors<br/>Mitogen-Activated Protein Kinase Kinases<br/>NF-KappaB Inhibitor alpha<br/>NF-kappa B--antagonists & inhibitors<br/>NF-kappa B p50 Subunit<br/>Nitriles<br/>Octamer Transcription Factor-1<br/>Okadaic Acid--antagonists & inhibitors<br/>Protein Binding--drug effects<br/>Protein Kinase Inhibitors<br/>Protein Kinases--metabolism<br/>Tetradecanoylphorbol Acetate--antagonists & inhibitors<br/>Toluidines<br/>Transcription Factor AP-1--metabolism<br/>Transcription Factor RelA<br/>Transcription Factors--metabolism<br/>Tumor Cells, Cultured<br/>Tumor Necrosis Factor-alpha--antagonists & inhibitors