TY - GEN AU - Hall,S D AU - Thummel,K E AU - Watkins,P B AU - Lown,K S AU - Benet,L Z AU - Paine,M F AU - Mayo,R R AU - Turgeon,D K AU - Bailey,D G AU - Fontana,R J AU - Wrighton,S A TI - Molecular and physical mechanisms of first-pass extraction SN - 0090-9556 PY - 1999///0407 KW - Animals KW - Biological Availability KW - Cytochrome P-450 CYP3A KW - Cytochrome P-450 Enzyme System KW - metabolism KW - Humans KW - Intestinal Absorption KW - Intestines KW - enzymology KW - Liver KW - Mixed Function Oxygenases KW - Pharmaceutical Preparations N1 - Publication Type: Congress; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review ER -