TY  - GEN
AU  - Fisher,J E
AU  - Rogers,M J
AU  - Halasy,J M
AU  - Luckman,S P
AU  - Hughes,D E
AU  - Masarachia,P J
AU  - Wesolowski,G
AU  - Russell,R G
AU  - Rodan,G A
AU  - Reszka,A A
TI  - Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro
SN  - 0027-8424
PY  - 1999///0301
KW  - Alendronate
KW  - pharmacology
KW  - Animals
KW  - Bone Resorption
KW  - metabolism
KW  - Cell Differentiation
KW  - drug effects
KW  - Cells, Cultured
KW  - Cholesterol
KW  - biosynthesis
KW  - Clodronic Acid
KW  - Diterpenes
KW  - Enzyme Activation
KW  - Farnesol
KW  - Hydroxymethylglutaryl-CoA Reductase Inhibitors
KW  - Lovastatin
KW  - Mevalonic Acid
KW  - Mice
KW  - Osteoclasts
KW  - cytology
KW  - Protein Kinases
KW  - Rabbits
KW  - Skull
KW  - Squalene
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1073/pnas.96.1.133
ER  -