TY  - GEN
AU  - Murugesan,N
AU  - Gu,Z
AU  - Stein,P D
AU  - Bisaha,S
AU  - Spergel,S
AU  - Girotra,R
AU  - Lee,V G
AU  - Lloyd,J
AU  - Misra,R N
AU  - Schmidt,J
AU  - Mathur,A
AU  - Stratton,L
AU  - Kelly,Y F
AU  - Bird,E
AU  - Waldron,T
AU  - Liu,E C
AU  - Zhang,R
AU  - Lee,H
AU  - Serafino,R
AU  - Abboa-Offei,B
AU  - Mathers,P
AU  - Giancarli,M
AU  - Seymour,A A
AU  - Webb,M L
AU  - Hunt,J T
TI  - Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308)
SN  - 0022-2623
PY  - 1999///0121
KW  - Administration, Oral
KW  - Animals
KW  - Aorta, Thoracic
KW  - drug effects
KW  - Blood Pressure
KW  - Carotid Arteries
KW  - Cerebellum
KW  - Endothelin Receptor Antagonists
KW  - Endothelin-1
KW  - pharmacology
KW  - Female
KW  - In Vitro Techniques
KW  - Injections, Intravenous
KW  - Isoxazoles
KW  - administration & dosage
KW  - Macaca fascicularis
KW  - Male
KW  - Rabbits
KW  - Radioligand Assay
KW  - Rats
KW  - Receptor, Endothelin A
KW  - Structure-Activity Relationship
KW  - Sulfonamides
KW  - Vasoconstriction
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm970872k
ER  -