Murugesan, N <br/><br/>
Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308).  [electronic resource] 

 -  Journal of medicinal chemistry  Dec 1998 
 - 5198-218 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm970872k  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Aorta, Thoracic--drug effects<br/>Blood Pressure--drug effects<br/>Carotid Arteries--drug effects<br/>Cerebellum--drug effects<br/>Endothelin Receptor Antagonists<br/>Endothelin-1--pharmacology<br/>Female<br/>In Vitro Techniques<br/>Injections, Intravenous<br/>Isoxazoles--administration & dosage<br/>Macaca fascicularis<br/>Male<br/>Rabbits<br/>Radioligand Assay<br/>Rats<br/>Receptor, Endothelin A<br/>Structure-Activity Relationship<br/>Sulfonamides--administration & dosage<br/>Vasoconstriction--drug effects