Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. [electronic resource]
- Molecular cell Nov 1998
- 581-91 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
1097-2765
10.1016/s1097-2765(00)80157-4 doi
Animals Apoptosis--drug effects Breast Neoplasms--genetics CDC2 Protein Kinase--antagonists & inhibitors CDC2-CDC28 Kinases Cell Line Cyclin B--metabolism Cyclin B1 Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinases--genetics Cyclins--genetics DNA Fragmentation Fibroblasts Flow Cytometry Humans Kinetin Mice Oligonucleotides, Antisense--genetics Paclitaxel--pharmacology Protein Serine-Threonine Kinases--genetics Purines--pharmacology Receptor, ErbB-2--genetics Transfection Tumor Cells, Cultured Up-Regulation--genetics