Corona, P <br/><br/>
Quinoxaline chemistry. Part 11. 3-Phenyl-2[phenoxy- and phenoxymethyl]-6(7) or 6,8-substituted quinoxalines and N-[4-(6(7)-substituted or 6,8-disubstituted-3-phenylquinoxalin-2-yl)hydroxy or hydroxymethyl] benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity and enzymatic inhibitory activity against dihydrofolate reductase and thymidylate synthase.  [electronic resource] 

 -  Farmaco (Societa chimica italiana : 1989)  Jul 1998 
 - 480-93 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article 
<br/><br/><label>ISSN: </label>0014-827X 
<br/><br/><label>Standard No.: </label>10.1016/s0014-827x(98)00054-8  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemistry<br/>Cattle<br/>Enzyme Inhibitors--chemistry<br/>Folic Acid Antagonists--pharmacology<br/>Humans<br/>Molecular Structure<br/>Quinoxalines--chemical synthesis<br/>Rats<br/>Structure-Activity Relationship<br/>Thymidylate Synthase--antagonists & inhibitors<br/>Tumor Cells, Cultured--drug effects