Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunction. [electronic resource]
- The Journal of thoracic and cardiovascular surgery Dec 1998
- 1060-8 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
0022-5223
10.1016/S0022-5223(98)70059-5 doi
Animals Antibodies, Monoclonal--therapeutic use Cardiopulmonary Bypass--adverse effects Chemotaxis, Leukocyte--drug effects Complement C5a--immunology Coronary Vessels--drug effects Endothelium, Vascular--drug effects Female Heart Arrest, Induced--adverse effects Hemodynamics--drug effects Male Mice Mice, Inbred BALB C Myocardial Reperfusion Injury--enzymology Neutrophils--drug effects Nitric Oxide Synthase--metabolism Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Peroxidase--metabolism Swine