TY - GEN AU - Gore,S D AU - Rowinsky,E K AU - Miller,C B AU - Griffin,C AU - Chen,T L AU - Borowitz,M AU - Donehower,R C AU - Burks,K L AU - Armstrong,D K AU - Burke,P J AU - Grever,M R AU - Kaufmann,S H TI - A phase II "window" study of topotecan in untreated patients with high risk adult acute lymphoblastic leukemia SN - 1078-0432 PY - 1999///0223 KW - Adult KW - Aged KW - Antineoplastic Agents KW - adverse effects KW - Bone Marrow KW - drug effects KW - DNA Topoisomerases, Type I KW - metabolism KW - Female KW - Humans KW - Leukocyte Count KW - Male KW - Middle Aged KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma KW - drug therapy KW - Proto-Oncogene Proteins c-bcl-2 KW - antagonists & inhibitors KW - Risk Factors KW - Topoisomerase I Inhibitors KW - Topotecan KW - Treatment Outcome N1 - Publication Type: Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, U.S. Gov't, P.H.S ER -