Treatment of resting zone chondrocytes with transforming growth factor-beta 1 induces differentiation into a phenotype characteristic of growth zone chondrocytes by downregulating responsiveness to 24,25-(OH)2D3 and upregulating responsiveness to 1,25-(OH)2D3. [electronic resource]
- Bone Nov 1998
- 465-70 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
8756-3282
10.1016/s8756-3282(98)00132-x doi
24,25-Dihydroxyvitamin D 3--pharmacology Alkaline Phosphatase--metabolism Animals Calcitriol--pharmacology Cell Differentiation--drug effects Cells, Cultured Chondrocytes--cytology Collagen--metabolism Dose-Response Relationship, Drug Down-Regulation--physiology Drug Synergism Phenotype Rats Rats, Sprague-Dawley Transforming Growth Factor beta--pharmacology Up-Regulation--physiology