Schwartz, Z

Treatment of resting zone chondrocytes with transforming growth factor-beta 1 induces differentiation into a phenotype characteristic of growth zone chondrocytes by downregulating responsiveness to 24,25-(OH)2D3 and upregulating responsiveness to 1,25-(OH)2D3. [electronic resource] - Bone Nov 1998 - 465-70 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

8756-3282

10.1016/s8756-3282(98)00132-x doi


24,25-Dihydroxyvitamin D 3--pharmacology
Alkaline Phosphatase--metabolism
Animals
Calcitriol--pharmacology
Cell Differentiation--drug effects
Cells, Cultured
Chondrocytes--cytology
Collagen--metabolism
Dose-Response Relationship, Drug
Down-Regulation--physiology
Drug Synergism
Phenotype
Rats
Rats, Sprague-Dawley
Transforming Growth Factor beta--pharmacology
Up-Regulation--physiology