TY  - GEN
AU  - Bruneau,J M
AU  - Yea,C M
AU  - Spinella-Jaegle,S
AU  - Fudali,C
AU  - Woodward,K
AU  - Robson,P A
AU  - Sautès,C
AU  - Westwood,R
AU  - Kuo,E A
AU  - Williamson,R A
AU  - Ruuth,E
TI  - Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide
SN  - 0264-6021
PY  - 1999///0126
KW  - Aniline Compounds
KW  - metabolism
KW  - Binding Sites
KW  - Binding, Competitive
KW  - Cell Division
KW  - drug effects
KW  - Cell Membrane
KW  - Crotonates
KW  - Dihydroorotate Dehydrogenase
KW  - Humans
KW  - Hydroxybutyrates
KW  - Lymphoma
KW  - enzymology
KW  - Nitriles
KW  - Oxidoreductases
KW  - antagonists & inhibitors
KW  - Oxidoreductases Acting on CH-CH Group Donors
KW  - Spleen
KW  - Toluidines
KW  - Tumor Cells, Cultured
KW  - Uridine
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1042/bj3360299
ER  -