TY  - GEN
AU  - Byrd,J C
AU  - Shinn,C
AU  - Waselenko,J K
AU  - Fuchs,E J
AU  - Lehman,T A
AU  - Nguyen,P L
AU  - Flinn,I W
AU  - Diehl,L F
AU  - Sausville,E
AU  - Grever,M R
TI  - Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53
SN  - 0006-4971
PY  - 1998///1221
KW  - Animals
KW  - Antineoplastic Agents
KW  - administration & dosage
KW  - Apoptosis
KW  - drug effects
KW  - Caspase 3
KW  - Caspases
KW  - physiology
KW  - Cell Cycle Proteins
KW  - Chromosomes, Human, Pair 17
KW  - genetics
KW  - Cyclin-Dependent Kinase Inhibitor p27
KW  - Drug Administration Schedule
KW  - Drug Resistance, Neoplasm
KW  - Drug Screening Assays, Antitumor
KW  - Enzyme Activation
KW  - Enzyme Precursors
KW  - metabolism
KW  - Flavonoids
KW  - Gene Deletion
KW  - Genes, p53
KW  - Growth Inhibitors
KW  - Humans
KW  - In Situ Hybridization, Fluorescence
KW  - Interleukin-4
KW  - pharmacology
KW  - Leukemia, Lymphocytic, Chronic, B-Cell
KW  - drug therapy
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Microtubule-Associated Proteins
KW  - biosynthesis
KW  - Neoplasm Proteins
KW  - Piperidines
KW  - Proto-Oncogene Proteins
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - Tumor Cells, Cultured
KW  - Tumor Suppressor Protein p53
KW  - Tumor Suppressor Proteins
KW  - Vidarabine
KW  - analogs & derivatives
KW  - bcl-2-Associated X Protein
N1  - Publication Type: Journal Article
ER  -