Byrd, J C <br/><br/>
Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.  [electronic resource] 

 -  Blood  Nov 1998 
 - 3804-16 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0006-4971 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--administration & dosage<br/>Apoptosis--drug effects<br/>Caspase 3<br/>Caspases--physiology<br/>Cell Cycle Proteins<br/>Chromosomes, Human, Pair 17--genetics<br/>Cyclin-Dependent Kinase Inhibitor p27<br/>Drug Administration Schedule<br/>Drug Resistance, Neoplasm<br/>Drug Screening Assays, Antitumor<br/>Enzyme Activation--drug effects<br/>Enzyme Precursors--metabolism<br/>Flavonoids--administration & dosage<br/>Gene Deletion<br/>Genes, p53<br/>Growth Inhibitors--administration & dosage<br/>Humans<br/>In Situ Hybridization, Fluorescence<br/>Interleukin-4--pharmacology<br/>Leukemia, Lymphocytic, Chronic, B-Cell--drug therapy<br/>Mice<br/>Mice, Inbred C57BL<br/>Mice, Knockout<br/>Microtubule-Associated Proteins--biosynthesis<br/>Neoplasm Proteins--biosynthesis<br/>Piperidines--administration & dosage<br/>Proto-Oncogene Proteins--biosynthesis<br/>Proto-Oncogene Proteins c-bcl-2--biosynthesis<br/>Tumor Cells, Cultured<br/>Tumor Suppressor Protein p53--physiology<br/>Tumor Suppressor Proteins<br/>Vidarabine--analogs & derivatives<br/>bcl-2-Associated X Protein