TY  - GEN
AU  - Klose,T S
AU  - Ibeanu,G C
AU  - Ghanayem,B I
AU  - Pedersen,L G
AU  - Li,L
AU  - Hall,S D
AU  - Goldstein,J A
TI  - Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen
SN  - 0003-9861
PY  - 1998///1007
KW  - Aryl Hydrocarbon Hydroxylases
KW  - Cytochrome P-450 CYP2C19
KW  - Cytochrome P-450 CYP2C9
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - Cytochrome P-450 Enzyme System
KW  - genetics
KW  - Diclofenac
KW  - metabolism
KW  - Enzyme Activation
KW  - drug effects
KW  - Escherichia coli
KW  - Humans
KW  - Hydroxylation
KW  - Ibuprofen
KW  - Mixed Function Oxygenases
KW  - Mutagenesis, Site-Directed
KW  - Protein Binding
KW  - Recombinant Fusion Proteins
KW  - Steroid 16-alpha-Hydroxylase
KW  - Steroid Hydroxylases
KW  - antagonists & inhibitors
KW  - Substrate Specificity
KW  - Tolbutamide
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1006/abbi.1998.0826
ER  -