Klose, T S <br/><br/>
Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen.  [electronic resource] 

 -  Archives of biochemistry and biophysics  Sep 1998 
 - 240-8 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0003-9861 
<br/><br/><label>Standard No.: </label>10.1006/abbi.1998.0826  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aryl Hydrocarbon Hydroxylases<br/>Cytochrome P-450 CYP2C19<br/>Cytochrome P-450 CYP2C9<br/>Cytochrome P-450 Enzyme Inhibitors<br/>Cytochrome P-450 Enzyme System--genetics<br/>Diclofenac--metabolism<br/>Enzyme Activation--drug effects<br/>Escherichia coli--genetics<br/>Humans<br/>Hydroxylation<br/>Ibuprofen--metabolism<br/>Mixed Function Oxygenases--genetics<br/>Mutagenesis, Site-Directed<br/>Protein Binding--drug effects<br/>Recombinant Fusion Proteins--genetics<br/>Steroid 16-alpha-Hydroxylase<br/>Steroid Hydroxylases--antagonists & inhibitors<br/>Substrate Specificity--genetics<br/>Tolbutamide--metabolism