Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production. [electronic resource]
- Molecular and cellular biology Sep 1998
- 5166-77 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0270-7306
10.1128/MCB.18.9.5166 doi
CD4-Positive T-Lymphocytes--cytology Cell Cycle Cell Line Cell Transformation, Viral Clone Cells Cytokines--biosynthesis DNA Methylation DNA Modification Methylases--biosynthesis Gene Expression Regulation, Enzymologic HIV Core Protein p24--biosynthesis HIV-1--immunology Humans Interferon-gamma--biosynthesis Polymerase Chain Reaction Promoter Regions, Genetic T-Lymphocytes--cytology T-Lymphocytes, Helper-Inducer--immunology