Lasker, J M

Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. [electronic resource] - Archives of biochemistry and biophysics May 1998 - 16-28 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0003-9861

10.1006/abbi.1998.0615 doi


Anti-Inflammatory Agents, Non-Steroidal--metabolism
Aryl Hydrocarbon Hydroxylases
Chromatography, DEAE-Cellulose
Chromatography, Ion Exchange
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C8
Cytochrome P-450 CYP2C9
Cytochrome P-450 Enzyme System--isolation & purification
Electrophoresis, Polyacrylamide Gel
Humans
Hydroxylation
Kinetics
Mephenytoin--pharmacokinetics
Microsomes, Liver--enzymology
Mixed Function Oxygenases--isolation & purification
Omeprazole--pharmacokinetics
Steroid 16-alpha-Hydroxylase
Steroid Hydroxylases--isolation & purification
Substrate Specificity
Tolbutamide--pharmacokinetics
Ultrafiltration