TY  - GEN
AU  - Silva,D J
AU  - Stubbe,J
AU  - Samano,V
AU  - Robins,M J
TI  - Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation
SN  - 0006-2960
PY  - 1998///0514
KW  - Cytosine
KW  - metabolism
KW  - Deoxyadenosines
KW  - Deoxycytidine
KW  - analogs & derivatives
KW  - Electron Spin Resonance Spectroscopy
KW  - Enzyme Activation
KW  - drug effects
KW  - Enzyme Inhibitors
KW  - chemistry
KW  - Enzyme Stability
KW  - Fluorides
KW  - Free Radicals
KW  - Lactobacillus
KW  - enzymology
KW  - Peptides
KW  - Protein Denaturation
KW  - Ribonucleotide Reductases
KW  - antagonists & inhibitors
KW  - Spectrophotometry, Ultraviolet
KW  - Sulfhydryl Compounds
KW  - pharmacology
KW  - Vitamin B 12
KW  - Gemcitabine
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1021/bi972934e
ER  -