TY  - GEN
AU  - Lavie,A
AU  - Konrad,M
AU  - Brundiers,R
AU  - Goody,R S
AU  - Schlichting,I
AU  - Reinstein,J
TI  - Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation
SN  - 0006-2960
PY  - 1998///0414
KW  - Biotransformation
KW  - Catalysis
KW  - drug effects
KW  - Crystallography, X-Ray
KW  - Dinucleoside Phosphates
KW  - chemistry
KW  - Enzyme Activation
KW  - Fungal Proteins
KW  - Herpesvirus 1, Human
KW  - enzymology
KW  - Humans
KW  - Kinetics
KW  - Macromolecular Substances
KW  - Models, Molecular
KW  - Nucleoside-Phosphate Kinase
KW  - antagonists & inhibitors
KW  - Saccharomyces cerevisiae
KW  - Schizosaccharomyces
KW  - Sequence Homology, Amino Acid
KW  - Substrate Specificity
KW  - Zidovudine
KW  - metabolism
N1  - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/bi9720787
ER  -