A single amino acid substitution in the human and a bacterial hypoxanthine phosphoribosyltransferase modulates specificity for the binding of guanine. [electronic resource]
- Biochemistry Mar 1998
- 3491-8 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
0006-2960
10.1021/bi9720179 doi
Amino Acid Sequence Base Sequence Binding Sites--genetics Crystallography, X-Ray DNA Primers--genetics Escherichia coli--genetics Genes, Bacterial Humans Hypoxanthine Phosphoribosyltransferase--chemistry In Vitro Techniques Kinetics Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Protein Conformation Recombinant Proteins--chemistry Salmonella typhimurium--enzymology Sequence Homology, Amino Acid Species Specificity Substrate Specificity