An Sp1-binding silencer element is a critical negative regulator of the megakaryocyte-specific alphaIIb gene. [electronic resource]
- The Journal of biological chemistry Mar 1998
- 5716-26 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.273.10.5716 doi
Animals Base Sequence Binding Sites--genetics Cell Line DNA-Binding Proteins--analysis Gene Expression Regulation, Developmental--genetics Genes, Reporter Humans Megakaryocytes--physiology Molecular Sequence Data Nuclear Proteins--analysis Platelet Glycoprotein GPIIb-IIIa Complex--genetics Point Mutation--genetics Promoter Regions, Genetic--genetics Rats Recombinant Proteins--genetics Sequence Deletion--genetics Sp1 Transcription Factor--genetics