mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway. [electronic resource]
- Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research Jan 1998
- 79-84 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1044-9523
Animals Cell Division--drug effects Cell Line Cysteine Endopeptidases--metabolism Cysteine Proteinase Inhibitors--pharmacology Humans Hydrolysis Leupeptins--pharmacology Multienzyme Complexes--metabolism Nuclear Proteins Proteasome Endopeptidase Complex Proto-Oncogene Proteins--genetics Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-mdm2 Tumor Suppressor Protein p53--metabolism Ubiquitins--metabolism bcl-2-Associated X Protein