TY  - GEN
AU  - Lau,C K
AU  - Black,W C
AU  - Belley,M
AU  - Chan,C
AU  - Charleson,S
AU  - Denis,D
AU  - Gauthier,J Y
AU  - Gordon,R
AU  - Guay,D
AU  - Hamel,P
AU  - Kargman,S
AU  - Leblanc,Y
AU  - Mancini,J
AU  - Ouellet,M
AU  - Percival,D
AU  - Prasit,P
AU  - Roy,P
AU  - Skorey,K
AU  - Tagari,P
AU  - Vickers,P
AU  - Wong,E
TI  - From indomethacin to a selective COX-2 inhibitor. Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors
SN  - 0065-2598
PY  - 1997///1230
KW  - Animals
KW  - Anti-Inflammatory Agents, Non-Steroidal
KW  - chemical synthesis
KW  - Carrageenan
KW  - toxicity
KW  - Chromium Radioisotopes
KW  - Cyclooxygenase 1
KW  - Cyclooxygenase 2
KW  - Cyclooxygenase 2 Inhibitors
KW  - Cyclooxygenase Inhibitors
KW  - Digestive System
KW  - drug effects
KW  - Edema
KW  - chemically induced
KW  - Feces
KW  - chemistry
KW  - Fever
KW  - Indomethacin
KW  - analogs & derivatives
KW  - Isoenzymes
KW  - Membrane Proteins
KW  - Molecular Conformation
KW  - Molecular Structure
KW  - Neoplasm Proteins
KW  - antagonists & inhibitors
KW  - Prostaglandin-Endoperoxide Synthases
KW  - Rats
KW  - Structure-Activity Relationship
KW  - Substrate Specificity
KW  - Tumor Cells, Cultured
N1  - Publication Type: Comparative Study; Journal Article
ER  -