Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus. [electronic resource]
- Biochemistry Jun 1997
- 7776-85 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0006-2960
10.1021/bi970648x doi
Animals Antibiotics, Antineoplastic--pharmacology Benzoquinones Biological Transport Cell Line Cell Nucleus--drug effects Cytoplasm--drug effects HSP90 Heat-Shock Proteins--metabolism Lactams, Macrocyclic Mice Protein Binding Quinones--pharmacology Receptors, Glucocorticoid--metabolism