TY  - GEN
AU  - Matherly,L H
AU  - Taub,J W
TI  - Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia
SN  - 1042-8194
PY  - 1997///0605
KW  - Adult
KW  - Antimetabolites, Antineoplastic
KW  - pharmacokinetics
KW  - Biological Transport
KW  - Biotransformation
KW  - Carrier Proteins
KW  - metabolism
KW  - Child
KW  - Chromosomes, Human, Pair 21
KW  - genetics
KW  - Disease Susceptibility
KW  - Disease-Free Survival
KW  - Down Syndrome
KW  - complications
KW  - Drug Resistance, Neoplasm
KW  - Folic Acid Antagonists
KW  - Half-Life
KW  - Humans
KW  - Membrane Proteins
KW  - Membrane Transport Proteins
KW  - Methotrexate
KW  - Neoplasm Proteins
KW  - Neoplastic Stem Cells
KW  - Polyglutamic Acid
KW  - Precursor Cell Lymphoblastic Leukemia-Lymphoma
KW  - drug therapy
KW  - Prognosis
KW  - Reduced Folate Carrier Protein
KW  - Remission Induction
KW  - Tetrahydrofolate Dehydrogenase
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
UR  - https://doi.org/10.3109/10428199609093433
ER  -