Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice. [electronic resource]
- Pain Dec 1996
- 229-37 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
0304-3959
10.1016/s0304-3959(96)03185-5 doi
Analgesics, Opioid--therapeutic use Animals Binding, Competitive Dizocilpine Maleate--therapeutic use Drug Tolerance Enkephalin, Ala(2)-MePhe(4)-Gly(5)- Enkephalins--therapeutic use Excitatory Amino Acid Antagonists--therapeutic use Fentanyl--therapeutic use Isoquinolines--therapeutic use Male Mice Mice, Inbred ICR Morphine--therapeutic use Oligopeptides--therapeutic use Receptors, N-Methyl-D-Aspartate--antagonists & inhibitors Receptors, Opioid, delta--agonists Receptors, Opioid, mu--agonists