TY  - GEN
AU  - Desiderio,M A
AU  - Bergamaschi,D
AU  - Mascellani,E
AU  - De Feudis,P
AU  - Erba,E
AU  - D'Incalci,M
TI  - Treatment with inhibitors of polyamine biosynthesis, which selectively lower intracellular spermine, does not affect the activity of alkylating agents but antagonizes the cytotoxicity of DNA topoisomerase II inhibitors
SN  - 0007-0920
PY  - 1997///0417
KW  - Alkynes
KW  - Antineoplastic Agents, Alkylating
KW  - pharmacology
KW  - Cell Cycle
KW  - drug effects
KW  - Cell Survival
KW  - DNA, Neoplasm
KW  - biosynthesis
KW  - Deoxyadenosines
KW  - Diamines
KW  - Enzyme Inhibitors
KW  - Female
KW  - Humans
KW  - Ornithine Decarboxylase Inhibitors
KW  - Ovarian Neoplasms
KW  - Polyamines
KW  - metabolism
KW  - Spermine
KW  - Topoisomerase II Inhibitors
KW  - Tumor Cells, Cultured
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/bjc.1997.176
ER  -