TY  - GEN
AU  - Jones,T R
AU  - Webber,S E
AU  - Varney,M D
AU  - Reddy,M R
AU  - Lewis,K K
AU  - Kathardekar,V
AU  - Mazdiyasni,H
AU  - Deal,J
AU  - Nguyen,D
AU  - Welsh,K M
AU  - Webber,S
AU  - Johnston,A
AU  - Matthews,D A
AU  - Smith,W W
AU  - Janson,C A
AU  - Bacquet,R J
AU  - Howland,E F
AU  - Booth,C L
AU  - Herrmann,S M
AU  - Ward,R W
AU  - White,J
AU  - Bartlett,C A
AU  - Morse,C A
TI  - Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase
SN  - 0022-2623
PY  - 1997///0417
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Cell Division
KW  - drug effects
KW  - Crystallography, X-Ray
KW  - Drug Screening Assays, Antitumor
KW  - Enzyme Inhibitors
KW  - Escherichia coli
KW  - enzymology
KW  - Humans
KW  - Magnetic Resonance Spectroscopy
KW  - Mice
KW  - Models, Molecular
KW  - Molecular Conformation
KW  - Molecular Structure
KW  - Neoplasms, Experimental
KW  - drug therapy
KW  - Quinazolines
KW  - Structure-Activity Relationship
KW  - Sulfones
KW  - Sulfoxides
KW  - Thymidylate Synthase
KW  - antagonists & inhibitors
KW  - Tumor Cells, Cultured
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm960613f
ER  -