Jones, T R <br/><br/>
Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.  [electronic resource] 

 -  Journal of medicinal chemistry  Feb 1997 
 - 677-83 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm960613f  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemical synthesis<br/>Cell Division--drug effects<br/>Crystallography, X-Ray<br/>Drug Screening Assays, Antitumor<br/>Enzyme Inhibitors--chemical synthesis<br/>Escherichia coli--enzymology<br/>Humans<br/>Magnetic Resonance Spectroscopy<br/>Mice<br/>Models, Molecular<br/>Molecular Conformation<br/>Molecular Structure<br/>Neoplasms, Experimental--drug therapy<br/>Quinazolines--chemical synthesis<br/>Structure-Activity Relationship<br/>Sulfones--chemical synthesis<br/>Sulfoxides--chemical synthesis<br/>Thymidylate Synthase--antagonists & inhibitors<br/>Tumor Cells, Cultured