Collagen II containing a Cys substitution for arg-alpha1-519. Homotrimeric monomers containing the mutation do not assemble into fibrils but alter the self-assembly of the normal protein. [electronic resource]
- The Journal of biological chemistry Mar 1997
- 6457-64 p. digital
Publication Type: Journal Article
0021-9258
10.1074/jbc.272.10.6457 doi
Amino Acid Sequence Arginine Collagen--chemistry Computer Simulation Cysteine Exostoses, Multiple Hereditary--genetics Humans Macromolecular Substances Microscopy, Electron Molecular Sequence Data Osteoarthritis--genetics Point Mutation Protein Binding Protein Denaturation Protein Structure, Tertiary Structure-Activity Relationship