TY  - GEN
AU  - Lamb,D C
AU  - Kelly,D E
AU  - Schunck,W H
AU  - Shyadehi,A Z
AU  - Akhtar,M
AU  - Lowe,D J
AU  - Baldwin,B C
AU  - Kelly,S L
TI  - The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity
SN  - 0021-9258
PY  - 1997///0415
KW  - Amino Acid Sequence
KW  - Animals
KW  - Antifungal Agents
KW  - pharmacology
KW  - Candida albicans
KW  - enzymology
KW  - Cytochrome P-450 Enzyme System
KW  - genetics
KW  - Drug Resistance, Microbial
KW  - Electron Spin Resonance Spectroscopy
KW  - Fluconazole
KW  - Humans
KW  - Kinetics
KW  - Molecular Sequence Data
KW  - Mutagenesis
KW  - Oxidoreductases
KW  - Rats
KW  - Restriction Mapping
KW  - Sequence Alignment
KW  - Sterol 14-Demethylase
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1074/jbc.272.9.5682
ER  -